Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
about
Ubiquitin-proteasome system as a modulator of cell fateThe Designability of Protein Switches by Chemical Rescue of Structure: Mechanisms of Inactivation and ReactivationFull and Partial Agonism of a Designed Enzyme SwitchSubstrate selection by the proteasome during degradation of protein complexesTargeting proteins for degradationDRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradationDirected evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cellsDevelopment and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes.A fluorescent reporter for mapping cellular protein-protein interactions in time and space.Synthetic strategies for studying embryonic development.Split-protein systems: beyond binary protein-protein interactionsPhotomodulation of protein trans-splicing through backbone photocaging of the DnaE split intein.The N-end rule pathway and regulation by proteolysisDiversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system.A bioorthogonal small-molecule-switch system for controlling protein function in live cells.Chemical biology strategies for posttranslational control of protein function.Exploiting protein destruction for constructive use.Tunable and reversible drug control of protein production via a self-excising degron.Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomicsAn intein-mediated modulation of protein stability system and its application to study human cytomegalovirus essential gene function.Natural products: chemical instruments to apprehend biological symphony.Brought to life: targeted activation of enzyme function with small molecules.Conditional glycosylation in eukaryotic cells using a biocompatible chemical inducer of dimerization.Chemical inducers of targeted protein degradation.Protein translocation as a tool: The current rapamycin story.Protein tango: the toolbox to capture interacting partners.The ends and means of artificially induced targeted protein degradation.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome systemIntroducing inducible fluorescent split cholesterol oxidase to mammalian cells.A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells.Making it easier to regulate protein stability.Destabilizing domains derived from the human estrogen receptor.Inhibitor mediated protein degradation.Precise control of protein concentration in living cells.Emerging Chemistry Strategies for Engineering Native Chromatin.Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules.An intein-cassette integration approach used for the generation of a split TEV protease activated by conditional protein splicing.Light-cleavable rapamycin dimer as an optical trigger for protein dimerization.
P2860
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P2860
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
@ast
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
@en
type
label
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
@ast
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
@en
prefLabel
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
@ast
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
@en
P2093
P2860
P356
P1476
Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt
@en
P2093
Edmund C Schwartz
Matthew R Pratt
Tom W Muir
P2860
P304
11209-11214
P356
10.1073/PNAS.0700816104
P407
P577
2007-06-11T00:00:00Z