Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

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Protein-protein interaction networks as a new perspective to evaluate distinct functional roles of voltage-dependent anion channel isoforms.

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Q47658275-1C778D05-D775-4CA0-9D8F-424A0085A5A9

P2860

Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

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Mild Alkalization Acutely Trig ...... ependent Anion Channel Binding

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Mild Alkalization Acutely Trig ...... ependent Anion Channel Binding

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Mild Alkalization Acutely Trig ...... ependent Anion Channel Binding

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Mild Alkalization Acutely Trig ...... ependent Anion Channel Binding

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Mild Alkalization Acutely Trig ...... ependent Anion Channel Binding

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Mild Alkalization Acutely Trig ...... ependent Anion Channel Binding

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P1476

Mild Alkalization Acutely Trig ...... ependent Anion Channel Binding

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P2093

Cung Hoa Thien Quach

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Jin Hee Lee

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Jin Won Park

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Kyung-Han Lee

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Kyung-Ho Jung

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Seung Hwan Moon

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Yearn Seong Choe

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Young Seok Cho

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P2860

Understanding the Warburg effect: the metabolic requirements of cell proliferation

A new view of carcinogenesis and an alternative approach to cancer therapy

Extracellular alkaline pH leads to increased metastatic potential of estrogen receptor silenced endocrine resistant breast cancer cells

On the Origin of Cancer Cells

Why do cancers have high aerobic glycolysis?

Bicarbonate increases tumor pH and inhibits spontaneous metastases.

Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells.

Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.

Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells.

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e0159529

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scholarly article

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10.1371/JOURNAL.PONE.0159529

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English

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2016-08-01T00:00:00Z

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27479079

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4968818

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Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

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Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

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P1476

P2093

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P1476

P2093

P2860

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P31

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P407

P433

P478

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P698

P932