about
The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancersExploring the effects of polymorphisms on cis-regulatory signal transduction responseEngineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae.Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis.Cardio-facio-cutaneous syndrome with precocious puberty, growth hormone deficiency and hyperprolactinemiaPhosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-HMAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking.Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgraftsCellular and molecular effects of yeast probiotics on cancer.A review of targeted therapies evaluated by the pediatric preclinical testing program for osteosarcoma.Interaction of tRNA with MEK2 in pancreatic cancer cellsHigh prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.In vivo severity ranking of Ras pathway mutations associated with developmental disorders.LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancerAdvances towards the design and development of personalized non-small-cell lung cancer drug therapy.Parallel imaging of Drosophila embryos for quantitative analysis of genetic perturbations of the Ras pathway.A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish.How activating mutations affect MEK1 regulation and function.Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect.New generation sequencing of targeted genes in the classical and the variant form of hairy cell leukemia highlights mutations in epigenetic regulation genes.Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
MEK genomics in development and disease
@ast
MEK genomics in development and disease
@en
type
label
MEK genomics in development and disease
@ast
MEK genomics in development and disease
@en
prefLabel
MEK genomics in development and disease
@ast
MEK genomics in development and disease
@en
P2860
P50
P921
P356
P1476
MEK genomics in development and disease
@en
P2093
Jennifer L Bromberg-White
P2860
P304
P356
10.1093/BFGP/ELS022
P5008
P577
2012-06-29T00:00:00Z