Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
about
Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsThe amyloid hypothesis of Alzheimer's disease at 25 yearsInteraction between therapeutic interventions for Alzheimer's disease and physiological Aβ clearance mechanismsMT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.Structural basis for the sheddase function of human meprin metalloproteinase at the plasma membraneProteomic Substrate Identification for Membrane Proteases in the BrainProteomics of protein post-translational modifications implicated in neurodegenerationβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1A tale of two drug targets: the evolutionary history of BACE1 and BACE2BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and ratsPhysiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPaseBACE1 is necessary for experience-dependent homeostatic synaptic plasticity in visual cortexFunction, therapeutic potential and cell biology of BACE proteases: current status and future prospects.β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypesBACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseTargeting the β secretase BACE1 for Alzheimer's disease therapy.Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis.Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP levelRegulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth.An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.Alzheimer's Disease: Lessons Learned from Amyloidocentric Clinical Trials.η-Secretase processing of APP inhibits neuronal activity in the hippocampus.Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.Future Therapeutics in Alzheimer's Disease: Development Status of BACE Inhibitors.Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearanceLRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In VivoExtracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampusSheddomeDB: the ectodomain shedding database for membrane-bound shed markers.β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defectsProteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving ProteasesSample preparation protocol for bottom-up proteomic analysis of the secretome of the islets of Langerhans.Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells.
P2860
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P2860
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Secretome protein enrichment i ...... protease substrates in neurons
@ast
Secretome protein enrichment i ...... protease substrates in neurons
@en
type
label
Secretome protein enrichment i ...... protease substrates in neurons
@ast
Secretome protein enrichment i ...... protease substrates in neurons
@en
prefLabel
Secretome protein enrichment i ...... protease substrates in neurons
@ast
Secretome protein enrichment i ...... protease substrates in neurons
@en
P2093
P2860
P50
P356
P1433
P1476
Secretome protein enrichment i ...... protease substrates in neurons
@en
P2093
Albrecht Hoffmeister
Alessio Colombo
Christiane Volbracht
Katarzyna Koroniak
Michael Willem
Sebastian Hogl
Stefan Bräse
Steffen Roßner
Ulrike Zeitschel
P2860
P304
P356
10.1038/EMBOJ.2012.173
P407
P577
2012-06-22T00:00:00Z