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A comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometryMacrolide antibiotics allosterically predispose the ribosome for translation arrest.Using simulations to provide the framework for experimental protein folding studiesMacrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome.Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stallingHigh-resolution structure of the Escherichia coli ribosome.Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel.Mechanisms of ribosome stalling by SecM at multiple elongation steps.Advances in the molecular dynamics flexible fitting method for cryo-EM modeling.Regional discrimination and propagation of local rearrangements along the ribosomal exit tunnel.Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factorCollective variable approaches for single molecule flexible fitting and enhanced sampling.Functional implications of ribosomal RNA methylation in response to environmental stress.Toward the rational design of macrolide antibiotics to combat resistance.Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.The dynamics of SecM-induced translational stalling.Measurement of average decoding rates of the 61 sense codons in vivo.Enhanced sampling and overfitting analyses in structural refinement of nucleic acids into electron microscopy mapsAnalyzing machupo virus-receptor binding by molecular dynamics simulationsCharge-driven dynamics of nascent-chain movement through the SecYEG transloconRibosome. Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo.A Novel Method to Evaluate Ribosomal Performance in Cell-Free Protein Synthesis Systems.A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration.Parametrization of macrolide antibiotics using the force field toolkit.RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview.Synthetic chimeras with orthogonal ribosomal proteins increase translation yields by recruiting mRNA for translation as measured by profiling active ribosomes.Natural Products as Platforms To Overcome Antibiotic Resistance.Cotranslational folding of spectrin domains via partially structured states.Effect of Nascent Peptide Steric Bulk on Elongation Kinetics in the Ribosome Exit Tunnel.Origins of the Mechanochemical Coupling of Peptide Bond Formation to Protein Synthesis.Protein synthesis. The delicate dance of translation and folding.Molecular dynamics for irradiation driven chemistry: application to the FEBID process*
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Mechanisms of SecM-mediated stalling in the ribosome
@ast
Mechanisms of SecM-mediated stalling in the ribosome
@en
type
label
Mechanisms of SecM-mediated stalling in the ribosome
@ast
Mechanisms of SecM-mediated stalling in the ribosome
@en
prefLabel
Mechanisms of SecM-mediated stalling in the ribosome
@ast
Mechanisms of SecM-mediated stalling in the ribosome
@en
P2093
P2860
P1433
P1476
Mechanisms of SecM-mediated stalling in the ribosome
@en
P2093
Daniel N Wilson
Eduard Schreiner
James Gumbart
Roland Beckmann
P2860
P304
P356
10.1016/J.BPJ.2012.06.005
P407
P577
2012-07-17T00:00:00Z