Cytosine methylation determines hot spots of DNA damage in the human P53 gene. - Wikidata - wikimedia - TriplyDB

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

http://www.wikidata.org/entity/Q36106985

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A small-cell lung cancer genome with complex signatures of tobacco exposure Sequence variation in the Fanconi anemia gene FAA Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence Genomic sequencing in cancer Genomic impact of cigarette smoke, with application to three smoking-related diseases Global methylation profiling of lung cancer identifies novel methylated genes TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review Accurate DNA fragment sizing by capillary electrophoresis with laser-induced fluorescence array for detection of sequence specificity of DNA damage High-risk myelodysplastic syndromes and hypermethylation of the p15Ink4B gene.Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer.Lung cancer: a modified epigenome.DNA methylation and cancer.Molecular and genetic aspects of lung cancer.Lung cancer in never smokers: molecular profiles and therapeutic implications.The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis.Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG-->TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells.Methylation levels at selected CpG sites in the factor VIII and FGFR3 genes, in mature female and male germ cells: implications for male-driven evolution Specific-mutational patterns of p53 gene in bladder transitional cell carcinoma among a group of Iraqi patients exposed to war environmental hazards.The role of genetics in the establishment and maintenance of the epigenome.Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase.A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA.Selective clonal expansion and microenvironmental permissiveness in tobacco carcinogenesis.Cytogenetics and molecular genetics of lung cancer.Significance of TP53 mutations in human cancer: a critical analysis of mutations at CpG dinucleotides.On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.A seven-gene CpG-island methylation panel predicts breast cancer progression Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.MTHFR polymorphisms, folate intake and carcinogen DNA adducts in the lung.Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a]pyrene-DNA adducts, and genomic DNA methylation in cord blood.CHEMICAL SELECTIVITY OF NUCLEOBASE ADDUCTION RELATIVE TO IN VIVO MUTATION SITES ON EXON 7 FRAGMENT OF P53 TUMOR SUPPRESSOR GENE Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection.

P2860

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P2860

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

http://www.wikidata.org/entity/Q36106985

description

1997 nî lūn-bûn

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1997年の論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年論文

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1997年论文

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1997年论文

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1997年论文

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name

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

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Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

@en

type

label

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

@ast

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

@en

prefLabel

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

@ast

Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

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Proceedings of the National Academy of Sciences of the United States of America

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Cytosine methylation determines hot spots of DNA damage in the human P53 gene.

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G P Pfeifer

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J X Chen

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M F Denissenko

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M S Tang

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P2860

Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation

Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability.

Altered chromosomal methylation patterns accompany oncogene-induced transformation of human bronchial epithelial cells.

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

Database of p53 gene somatic mutations in human tumors and cell lines.

(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to mice

X-chromosome inactivation and cell memory.

TP53 tumor suppressor gene: a model for investigating human mutagenesis.

The 5-methylcytosine content of DNA from human tumors.

Methylation, mutation and cancer.

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