Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.
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Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in CellsImpact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein.Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in the C57BL/6 Mouse Model of Alzheimer's Disease.Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites.Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing.Binding of Bexarotene to the Amyloid Precursor Protein Transmembrane Domain in Liposomes Alters its α-Helical Conformation but Inhibits γ-Secretase Non-Selectively.
P2860
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P2860
Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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2015年论文
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name
Analysis by a highly sensitive ...... and its impact on processing.
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Analysis by a highly sensitive ...... and its impact on processing.
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type
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Analysis by a highly sensitive ...... and its impact on processing.
@ast
Analysis by a highly sensitive ...... and its impact on processing.
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prefLabel
Analysis by a highly sensitive ...... and its impact on processing.
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Analysis by a highly sensitive ...... and its impact on processing.
@en
P2093
P2860
P50
P1433
P1476
Analysis by a highly sensitive ...... and its impact on processing.
@en
P2093
Jean-Noël Octave
Laetitia El Haylani
Marie Decock
Steven O Smith
P2860
P304
P356
10.1016/J.FOB.2015.09.002
P577
2015-09-06T00:00:00Z