Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations
about
The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanismProbing the Active Center of Benzaldehyde Lyase with Substitutions and the Pseudosubstrate Analogue Benzoylphosphonic Acid Methyl Ester †Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylaseStructure and Function of the Catalytic Domain of the Dihydrolipoyl Acetyltransferase Component in Escherichia coli Pyruvate Dehydrogenase ComplexA δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activityStructural basis for activation of the thiamin diphosphate-dependent enzyme oxalyl-CoA decarboxylase by adenosine diphosphate.The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymesAcetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and Escherichia coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex.EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate:ferredoxin oxidoreductaseElectronic and nuclear magnetic resonance spectroscopic features of the 1',4'-iminopyrimidine tautomeric form of thiamin diphosphate, a novel intermediate on enzymes requiring this coenzymeReaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps.Catalysis in Enzymatic Decarboxylations: Comparison of Selected Cofactor-dependent and Cofactor-independent Examples.Nuclear magnetic resonance approaches in the study of 2-oxo acid dehydrogenase multienzyme complexes--a literature review.Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies.Synthesis with good enantiomeric excess of both enantiomers of alpha-ketols and acetolactates by two thiamin diphosphate-dependent decarboxylases.Electron density reactivity indexes of the tautomeric/ionization forms of thiamin diphosphate.Density-functional study on the equilibria in the ThDP activation.A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct.Factors mediating activity, selectivity, and substrate specificity for the thiamin diphosphate-dependent enzymes benzaldehyde lyase and benzoylformate decarboxylase.
P2860
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P2860
Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations
description
2005 nî lūn-bûn
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
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2005年论文
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2005年论文
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2005年论文
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name
Experimental observation of th ...... erived from these observations
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Experimental observation of th ...... erived from these observations
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type
label
Experimental observation of th ...... erived from these observations
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Experimental observation of th ...... erived from these observations
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prefLabel
Experimental observation of th ...... erived from these observations
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Experimental observation of th ...... erived from these observations
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P2860
P1433
P1476
Experimental observation of th ...... erived from these observations
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P2093
Frank Jordan
Natalia S Nemeria
P2860
P304
P356
10.1016/J.BIOORG.2005.02.001
P577
2005-04-01T00:00:00Z