Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel.
about
Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4Formation of heteromeric Kv2 channels in mammalian brain neuronsRearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gatingNitric oxide is an activity-dependent regulator of target neuron intrinsic excitabilitySelective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity.Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons.Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial nodeThe electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.A SUMO-Phospho tag team for wrestling with potassium channel gating.Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus.Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini.Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ ChannelsKv1.3 contains an alternative C-terminal ER exit motif and is recruited into COPII vesicles by Sec24a.Dynamic modulation of the kv2.1 channel by SRC-dependent tyrosine phosphorylationThe C-terminus of neuronal Kv2.1 channels is required for channel localization and targeting but not for NMDA-receptor-mediated regulation of channel functionDistinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal NeuronsTarget of HIV-1 Envelope Glycoprotein gp120-Induced Hippocampal Neuron Damage: Role of Voltage-Gated K(+) Channel Kv2.1.The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channelConvergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.Two di-leucine motifs regulate trafficking and function of mouse ASIC2a.Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics.Regulation of Kv2.1 K(+) conductance by cell surface channel density.Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels.Cytoplasmic domains and voltage-dependent potassium channel gating.Electrically silent Kv subunits: their molecular and functional characteristics.The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms.Domain structure and conformational changes in rat KV2.1 ion channel.Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling.Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents.
P2860
Q24324513-B620FBC2-2CB5-4C3B-A88D-5B2315B39786Q28564948-5B4A661D-3FF7-4823-AB66-1436DDE0D11BQ28573589-43ADC1A1-DDEA-47B8-9524-671A7A67F3DFQ30471925-AE6D77FE-6215-40D1-8D7E-E609E5634B91Q33493069-26138CF4-2CAF-4D53-B7C3-1D69D416F456Q33553671-1903FCE4-B61D-447F-A67C-8E70A484DF4AQ33675776-CF8D82F7-C3AF-4118-ABD0-D940276ABAEBQ34096457-B6F4BF35-EAED-4FA0-A622-68093FD02474Q34277792-56A4DEC2-A05D-4A6C-A6F8-9A1DC81C6AB6Q34390785-D2A82154-A641-46C1-9347-B5F9645962EBQ34865527-1F226EC5-E551-48A4-A9BA-2B4858D9607AQ34983529-B0A4D63F-E6E0-4457-B5F3-02E34A72921BQ35006443-2E9D9745-9EB4-42F4-9016-DBD0A0D81461Q35182181-48291DAE-3F37-49C2-81B2-4F3815E73EC3Q35675675-983176FF-4970-4C67-8366-1F7CD0713BBAQ35686448-EB49B67C-EF07-4AFE-B675-04BE178AAECFQ35736719-2AA4DE58-0078-4807-AD3C-9A1F412F7A32Q36059019-4090EC9E-A99F-46EA-B5A7-F471FCA1B70AQ36254121-6535B762-B860-4AC0-92BA-271729F511FFQ36274448-B0F02735-D3E1-4E1A-8D7C-7503180EEB48Q36288569-2254670A-48B6-4E3B-A21E-3FC5AD7C134AQ36378257-4EB4AE16-000D-41F4-9FA5-2CA03645AF7FQ36444002-16C0D9E2-B34E-41BA-9C23-933EBA1212B0Q36508894-17DCEF77-1043-42C3-A2E4-E655BB5C1DB9Q36532376-E55C4960-E181-493B-9FD2-734A57CF30F8Q37012313-0374B9BC-A354-4A5C-87D6-BE6AA7A031E5Q37798911-9EAA3DDE-89E3-48C4-8C29-743AA161D84DQ37999317-1F642D45-C3F8-40B0-8900-59CD94A862E3Q38002836-35A101DF-15E1-497F-8963-183311E2B722Q39292465-E7D20CEA-9755-4A90-8D4B-EC2D29F6B2DCQ42685144-DA7384CC-6C0B-4D4D-8B9A-16583CA04465Q45923768-BAA4B296-C9F8-4F04-A809-B960621BFA29Q51748184-88105A0D-7953-48CE-98B2-1A22E0D41EEF
P2860
Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Interdomain cytoplasmic intera ...... dulation of the Kv2.1 channel.
@ast
Interdomain cytoplasmic intera ...... dulation of the Kv2.1 channel.
@en
type
label
Interdomain cytoplasmic intera ...... dulation of the Kv2.1 channel.
@ast
Interdomain cytoplasmic intera ...... dulation of the Kv2.1 channel.
@en
prefLabel
Interdomain cytoplasmic intera ...... dulation of the Kv2.1 channel.
@ast
Interdomain cytoplasmic intera ...... dulation of the Kv2.1 channel.
@en
P2860
P1476
Interdomain cytoplasmic intera ...... odulation of the Kv2.1 channel
@en
P2093
Dominic F Siino
James S Trimmer
P2860
P304
P356
10.1523/JNEUROSCI.0186-08.2008
P407
P577
2008-05-01T00:00:00Z