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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

http://www.wikidata.org/entity/Q36133352

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Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data Dissecting the genetics of complex traits using summary association statistics Developing and evaluating polygenic risk prediction models for stratified disease prevention.Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.Reproductive fitness and genetic risk of psychiatric disorders in the general population.Leveraging functional annotations in genetic risk prediction for human complex diseases.Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.Polygenic Scores in Epidemiology: Risk Prediction, Etiology, and Clinical Utility Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.Reflections on the Field of Human Genetics: A Call for Increased Disease Genetics Theory Genome-Wide Estimates of Heritability for Social Demographic Outcomes Genetic evidence for natural selection in humans in the contemporary United States Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders.Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia.Epigenetic and genetic components of height regulation.SNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE.Selection against variants in the genome associated with educational attainment Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.Polygenic Risk Score for Schizophrenia and Treatment-Resistant Schizophrenia.Embracing polygenicity: a review of methods and tools for psychiatric genetics research.Polygenic risk for schizophrenia and neurocognitive performance in patients with schizophrenia.Testing familial transmission of smoking with two different research designs.Polygenic scores via penalized regression on summary statistics.Critical Issues in the Inclusion of Genetic and Epigenetic Information in Prevention and Intervention Trials.Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development.Endophenotype best practices.Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits.Integrative genetic risk prediction using non-parametric empirical Bayes classification.Nationwide Genomic Study in Denmark Reveals Remarkable Population Homogeneity.A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics Multimarker analysis suggests the involvement of BDNF signaling and microRNA biosynthesis in suicidal behavior.Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.Associations between subjective well-being and subcortical brain volumes.Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population.Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.Improving polygenic risk prediction from summary statistics by an empirical Bayes approach.A machine-learning heuristic to improve gene score prediction of polygenic traits.

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P2860

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

http://www.wikidata.org/entity/Q36133352

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

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J.AJHG.2015.09.001

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American Journal of Human Genetics

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

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Alexander Gusev

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Alkes L Price

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Benjamin Neale

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Bjarni J Vilhjálmsson

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Carlos Pato

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Daniel Chasman

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Eimear E Kenny

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Eli Stahl

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Gaurav Bhatia

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Gillian Belbin

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P2860

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Biological insights from 108 schizophrenia-associated genetic loci

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Genome-wide association study identifies five new schizophrenia loci

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

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576-592

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10.1016/J.AJHG.2015.09.001

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Michael E. Goddard

Sekar Kathiresan

Mikkel Heide Schierup

Peter M. Visscher

Mark Joseph Daly

Nikolaos A. Patsopoulos

Bogdan Pasaniuc

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2015-10-01T00:00:00Z

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26430803

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