Pharmacological study of the novel compound FLZ against experimental Parkinson's models and its active mechanism.

Pharmacological study of the novel compound FLZ against experimental Parkinson's models and its active mechanism.

Item
http://www.wikidata.org/entity/Q36161888
P-glycoprotein mediated efflux limits the transport of the novel anti-Parkinson's disease candidate drug FLZ across the physiological and PD pathological in vitro BBB modelsProtective effects of compound FLZ on beta-amyloid peptide-(25-35)-induced mouse hippocampal injury and learning and memory impairment.A novel cyclic squamosamide analogue compound FLZ improves memory impairment in artificial senescence mice induced by chronic injection of D-galactose and NaNO2.An in vivo microdialysis study of FLZ penetration through the blood-brain barrier in normal and 6-hydroxydopamine induced Parkinson's disease model rats.Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity.Squamosamide derivative FLZ inhibits TNF-α-induced ICAM-1 expression via down-regulation of the NF-κB signaling pathway in ARPE-19 cells.Compound FLZ inhibits lipopolysaccharide-induced inflammatory effects via down-regulation of the TAK-IKK and TAK-JNK/p38MAPK pathways in RAW264.7 macrophagesProtective effects of compound FLZ, a novel synthetic analogue of squamosamide, on beta-amyloid-induced rat brain mitochondrial dysfunction in vitro.FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells.Novel squamosamide derivative (compound FLZ) attenuates Abeta25-35-induced toxicity in SH-SY5Y cells.FLZ, synthetic squamosamide cyclic derivative, attenuates memory deficit and pathological changes in mice with experimentally induced aging.
P2860

Pharmacological study of the novel compound FLZ against experimental Parkinson's models and its active mechanism.

Item
http://www.wikidata.org/entity/Q36161888
description
2005 nî lūn-bûn
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
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2005年论文
@zh-cn
name
Pharmacological study of the n ...... dels and its active mechanism.
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Pharmacological study of the n ...... dels and its active mechanism.
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type
label
Pharmacological study of the n ...... dels and its active mechanism.
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Pharmacological study of the n ...... dels and its active mechanism.
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prefLabel
Pharmacological study of the n ...... dels and its active mechanism.
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Pharmacological study of the n ...... dels and its active mechanism.
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P1433
P1476
P2093
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P6179
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Pharmacological study of the n ...... dels and its active mechanism.
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P2093
P2888
P304
P31
P356
P433
P478
P577
P6179
P698