ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.
about
Cyclin-dependent kinase inhibitor therapy for hematologic malignanciesKnow the enemy as well as the weapons in hand: the aberrant death pathways and therapeutic agents in chronic lymphocytic leukemiaNew potential therapeutic approach for the treatment of B-Cell malignancies using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticlesInhibition of mTOR-dependent autophagy sensitizes leukemic cells to cytarabine-induced apoptotic deathMetabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cellsDisruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia.Flavopiridol can be safely administered using a pharmacologically derived schedule and demonstrates activity in relapsed and refractory non-Hodgkin's lymphoma.Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanismAutophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cellsUp-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia.Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells.Final results of EFC6663: a multicenter, international, phase 2 study of alvocidib for patients with fludarabine-refractory chronic lymphocytic leukemia.Vincristine activates c-Jun N-terminal kinase in chronic lymphocytic leukaemia in vivoInterplay between unfolded protein response and autophagy promotes tumor drug resistanceING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.The roles of BTG3 expression in gastric cancer: a potential marker for carcinogenesis and a target molecule for gene therapy.Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR PathwayMultiple CDK inhibitor dinaciclib suppresses neuroblastoma growth via inhibiting CDK2 and CDK9 activityEmerging drug profile: cyclin-dependent kinase inhibitorsIdentification of endoplasmic reticulum stress-inducing agents by antagonizing autophagy: a new potential strategy for identification of anti-cancer therapeutics in B-cell malignanciesAutophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.Endoplasmic Reticulum Stress and Related Pathological Processes.Simultaneous inhibition of Vps34 kinase would enhance PI3Kδ inhibitor cytotoxicity in the B-cell malignancies.A phase I trial of flavopiridol in relapsed multiple myeloma.Comparative drug screening in NUT midline carcinoma.A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabineDeath-associated Protein Kinase-1 Expression and Autophagy in Chronic Lymphocytic Leukemia Are Dependent on Activating Transcription Factor-6 and CCAAT/Enhancer-binding Protein-β.Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia.Recent progress of cyclin-dependent kinase inhibitors as potential anticancer agents.Potential Use of Flavopiridol in Treatment of Chronic Diseases.Suppression of autophagy enhanced growth inhibition and apoptosis of interferon-β in human glioma cells.Targeting autophagy in cancer.SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response.MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy.The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells.Endoplasmic reticulum stress-mediated autophagy protects against β,β-dimethylacrylshikonin-induced apoptosis in lung adenocarcinoma cells.
P2860
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P2860
ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
ER stress and autophagy: new d ...... kinase inhibitor flavopiridol.
@ast
ER stress and autophagy: new d ...... kinase inhibitor flavopiridol.
@en
type
label
ER stress and autophagy: new d ...... kinase inhibitor flavopiridol.
@ast
ER stress and autophagy: new d ...... kinase inhibitor flavopiridol.
@en
prefLabel
ER stress and autophagy: new d ...... kinase inhibitor flavopiridol.
@ast
ER stress and autophagy: new d ...... kinase inhibitor flavopiridol.
@en
P2093
P2860
P1433
P1476
ER stress and autophagy: new d ...... kinase inhibitor flavopiridol.
@en
P2093
Amy J Johnson
Amy J Wagner
Amy Lehman
David M Lucas
Emilia Mahoney
Jeffrey A Jones
Joseph M Flynn
Kristie A Blum
Leslie Andritsos
P2860
P304
P356
10.1182/BLOOD-2011-12-400184
P407
P50
P577
2012-06-27T00:00:00Z