Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. - Wikidata - wikimedia - TriplyDB

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

http://www.wikidata.org/entity/Q36169754

about

NMR Meets Tau: Insights into Its Function and Pathology Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.The release and trans-synaptic transmission of Tau via exosomes Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies Glial contributions to neurodegeneration in tauopathies.Characterization of TauC3 antibody and demonstration of its potential to block tau propagation Tau secretion is correlated to an increase of Golgi dynamics.Neuronal activity enhances tau propagation and tau pathology in vivo.Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.Three-Dimensional Models of the Human Brain Development and Diseases.Tau and neurodegenerative disease: the story so far.Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.Enhanced Tau Aggregation in the Presence of Amyloid β.Opportunities and challenges in modeling human brain disorders in transgenic primates.Prion-like propagation as a pathogenic principle in frontotemporal dementia.Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.Cellular Models for the Study of Prions.Formation, release, and internalization of stable tau oligomers in cells.Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus.Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins A Microfluidic Platform for the Characterisation of CNS Active Compounds.Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.Soluble Tau has devastating effects on the structural plasticity of hippocampal granule neurons.Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.Tauopathies: Mechanisms and Therapeutic Strategies.Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease.Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia.Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice.Does traumatic brain injury hold the key to the Alzheimer's disease puzzle?3D Miniaturization of Human Organs for Drug Discovery.In Vitro Microfluidic Models for Neurodegenerative Disorders.Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model.Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts.Alzheimer disease: Evidence for trans-synaptic and exo-synaptic tau propagation in Alzheimer disease.MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates.Tau protein liquid-liquid phase separation can initiate tau aggregation.Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain.Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

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Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

http://www.wikidata.org/entity/Q36169754

description

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Neuronal uptake and propagatio ...... rom Alzheimer's disease brain.

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Neuronal uptake and propagatio ...... rom Alzheimer's disease brain.

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Neuronal uptake and propagatio ...... rom Alzheimer's disease brain.

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Allyson D Roe

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Caitlin Commins

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Chloe K Nobuhara

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Daniel J Müller

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George A Carlson

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Isabel Costantino

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Matthew P Frosch

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Rose Pitstick

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Samantha B Nicholls

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Sarah L DeVos

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Transmission and spreading of tauopathy in transgenic mouse brain

Mechanisms of protein seeding in neurodegenerative diseases

Neuropathological stageing of Alzheimer-related changes

Trans-synaptic spread of tau pathology in vivo

Tau suppression in a neurodegenerative mouse model improves memory function

Propagation of tau pathology in a model of early Alzheimer's disease

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.

On-demand, competing gradient arrays for neutrophil chemotaxis.

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.

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10.1038/NCOMMS9490

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26458742

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Alzheimer's disease

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4608380

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