Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. - Wikidata - wikimedia - TriplyDB

Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

http://www.wikidata.org/entity/Q36174752

about

A Clickable Analogue of Ketamine Retains NMDA Receptor Activity, Psychoactivity, and Accumulates in Neurons.Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.Neurosteroids and GABAergic signaling in health and disease New perspectives in neurosteroid action: open questions for future research.GABAA receptor modulation by neurosteroids in models of temporal lobe epilepsies.Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.A propofol binding site on mammalian GABAA receptors identified by photolabeling Assessment of direct gating and allosteric modulatory effects of meprobamate in recombinant GABA(A) receptors.Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye.Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.Sites and functional consequence of VDAC-alkylphenol anesthetic interactions.11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChR In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets.Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.Mechanisms revealed through general anesthetic photolabeling.Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites!Orthosteric- versus allosteric-dependent activation of the GABAA receptor requires numerically distinct subunit level rearrangements.Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors.Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol.Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.Possible binding sites and interactions of propanidid and AZD3043 within the γ-aminobutyric acid type A receptor (GABAAR).Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites.Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.Structural basis for GABAA receptor potentiation by neurosteroids.A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.Analysis of γ-aminobutyric acid (GABA) type A receptor subtypes using isosteric and allosteric ligands.Neurosteroid regulation of GABA receptors: A role in catamenial epilepsy

P2860

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P2860

Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

http://www.wikidata.org/entity/Q36174752

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Neurosteroid analog photolabel ...... bunit of the GABA(A) receptor.

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Neurosteroid analog photolabel ...... bunit of the GABA(A) receptor.

@en

type

label

Neurosteroid analog photolabel ...... bunit of the GABA(A) receptor.

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Neurosteroid analog photolabel ...... bunit of the GABA(A) receptor.

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prefLabel

Neurosteroid analog photolabel ...... bunit of the GABA(A) receptor.

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Neurosteroid analog photolabel ...... bunit of the GABA(A) receptor.

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Molecular Pharmacology

P1476

Neurosteroid analog photolabel ...... bunit of the GABA(A) receptor.

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P2093

Alex S Evers

http://www.w3.org/2001/XMLSchema#string

Brad Manion

http://www.w3.org/2001/XMLSchema#string

David E Reichert

http://www.w3.org/2001/XMLSchema#string

Douglas F Covey

http://www.w3.org/2001/XMLSchema#string

Joe Henry Steinbach

http://www.w3.org/2001/XMLSchema#string

Karoline Fuchs

http://www.w3.org/2001/XMLSchema#string

R Reid Townsend

http://www.w3.org/2001/XMLSchema#string

Werner Sieghart

http://www.w3.org/2001/XMLSchema#string

Zi-Wei Chen

http://www.w3.org/2001/XMLSchema#string

P2860

MUSCLE: multiple sequence alignment with high accuracy and high throughput

Calibration of mass spectrometric peptide mass fingerprint data without specific external or internal calibrants.

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Principles of activation and permeation in an anion-selective Cys-loop receptor

Comparative protein modelling by satisfaction of spatial restraints

T-Coffee: A novel method for fast and accurate multiple sequence alignment

A statistical model for identifying proteins by tandem mass spectrometry

Neurosteroid access to the GABAA receptor

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

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408-419

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10.1124/MOL.112.078410

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3

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82

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2012-05-30T00:00:00Z

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225080976

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22648971

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P921

transmembrane protein

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3422701

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