Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
about
Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool.Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.Functional interrogation of non-coding DNA through CRISPR genome editing.Progress in Genome Editing Technology and Its Application in Plants.Correction of Monogenic and Common Retinal Disorders with Gene Therapy.Progress and prospects in plant genome editing.Editing the genome of hiPSC with CRISPR/Cas9: disease models.Genome-wide target specificities of CRISPR RNA-guided programmable deaminases.Functional variomics and network perturbation: connecting genotype to phenotype in cancer.Treatment of Dyslipidemia Using CRISPR/Cas9 Genome Editing.Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusionsCRISPR-STOP: gene silencing through base-editing-induced nonsense mutations.In Vivo Base Editing of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) as a Therapeutic Alternative to Genome Editing.Immunity to CRISPR Cas9 and Cas12a therapeutics.Genome Editing: The Recent History and Perspective in Cardiovascular Diseases.A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription.Editing the Genome Without Double-Stranded DNA Breaks.The impact of rare variation on gene expression across tissues.CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine.CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons.Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1.Am I ready for CRISPR? A user's guide to genetic screens.Target Discovery for Precision Medicine Using High-Throughput Genome Engineering.High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes.CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens.CRISPR-mediated Ophthalmic Genome Surgery.CRISPR in the Retina: Evaluation of Future Potential.CRISPR-Cas9 Genome Editing for Treatment of Atherogenic Dyslipidemia.Cas9, Cpf1 and C2c1/2/3-What's next?CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation.Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes.CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.CRISPR/Cas9-mediated noncoding RNA editing in human cancers.Harnessing natural DNA modifying activities for editing of the genome and epigenome.Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells.Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion.A Rice Dual-localized Pentatricopeptide Repeat Protein is involved in Organellar RNA Editing together with OsMORFs.
P2860
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P2860
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
@ast
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
@en
type
label
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
@ast
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
@en
prefLabel
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
@ast
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
@en
P2093
P2860
P356
P1433
P1476
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
@en
P2093
Cameron H Lee
Karlene A Cimprich
Michael C Bassik
Stephen B Montgomery
P2860
P2888
P304
P356
10.1038/NMETH.4038
P577
2016-10-31T00:00:00Z