The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury. - Wikidata - wikimedia - TriplyDB

The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.

The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.

http://www.wikidata.org/entity/Q36179559

about

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy An outline of necrosome triggers Necroptosis in acute kidney injury: a shedding light Interleukin-1 Family Cytokines in Liver Diseases Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.Necroptotic signaling in adaptive and innate immunity.RIP kinases: key decision makers in cell death and innate immunity.Aminotriazole alleviates acetaminophen poisoning via downregulating P450 2E1 and suppressing inflammation Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics.Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition.The serine threonine kinase RIP3: lost and found.Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells Anti-inflammatory effects of dabrafenib in vitro and in vivo.Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis.Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4(+)CD25(+) regulatory T cells Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.Necroptosis: an alternative cell death program defending against cancer.Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses.Emerging therapeutic targets for Gaucher disease.Necroinflammation in Kidney Disease.Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure.Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells.Generation of small molecules to interfere with regulated necrosis.Lysis of human neutrophils by community-associated methicillin-resistant Staphylococcus aureus.Biomarkers for the detection of necroptosis.The in vivo evidence for regulated necrosis.Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.Suppressive effects of dabrafenib on endothelial protein C receptor shedding.Necroptosis in cancer: An angel or a demon?Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis.Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.Necroptosis: Mechanisms and Relevance to Disease.Absence of RIPK3 predicts necroptosis resistance in malignant melanoma.Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells.Acetaminophen knocks on death's door and receptor interacting protein 1 kinase answers.

P2860

Q26739959-F5D27DA5-2730-4DEC-A6A8-FD958CC94FE3 Q26751108-B3DEBACD-5E26-424C-874E-D8CB2DED963A Q26764791-BFF94BF5-6390-4AFB-8CC6-4C8C6BAA6535 Q26778553-DCB3B34E-6AE2-4598-B4DD-BDB09B1C6931 Q28077079-36715539-E941-49E6-A88F-44328DE96B2D Q30396736-6A69AABB-F747-4A17-8A07-0C391C7D7A89 Q33848167-E3727197-0DBC-4A60-BA71-6F93DF90CFFF Q34339233-0F6C7D7C-69CF-4A9D-9876-A1185E68250A Q34924104-9EEAB01D-92F8-4B5C-911A-3CDA4D9D7592 Q35605545-0753031C-396D-47A1-8DA9-8BD4E50F0292 Q35686077-992B1486-E59A-4303-AABE-C4D68CEE0D64 Q35832271-62D6F9D0-28F0-449C-B284-584522EA2817 Q36082572-79EA7A83-8A2B-45AC-BA19-BBEBD43ABEBC Q36140709-CE27F04D-FFEA-4012-9BBC-822D14243378 Q36273868-97F81086-D2DA-4AB5-843B-F83AB26E78C7 Q36346954-0D4657DD-24C8-4138-9EAD-E1C8BC6AB370 Q36751262-F52DA69A-3BD3-4E23-9FB3-1C98AF60AB3A Q36826771-10FC0B4D-8881-494C-BDAD-755ED9AB687D Q36852508-F12957C3-5E75-4EB1-899C-91A28A74C9CB Q36880241-3605EFB4-A04D-43EE-8648-921E67152EAE Q37024803-7E03D7B3-31F8-4B96-85A1-0B2B693CE07E Q38270518-C84A5545-50E9-4B46-BBFB-41AC0EE0D30A Q38579499-590CBDA3-FF3A-48FF-8E35-00EF62495854 Q38759786-EFE88012-DFF9-4DF7-98B2-8E5C71922D2C Q38788869-65B84C92-8473-4622-9A61-F1AE0E8130F3 Q38799144-36E57A4F-0822-4CCA-91D9-2F6D066B0F34 Q38803317-CE9FF1DB-D1C5-4ADB-B4CA-AFDEFF831EB8 Q38804928-3329A936-852B-4BFC-9F01-B78F34CFEA31 Q38809791-62D869FA-C1E1-405D-A301-64B21D1CC606 Q38861198-7BB7564D-0AD6-415B-93C6-0A4DA68A3FE7 Q38871980-EDED911D-EDE9-413F-9B91-CC6438CB5BE0 Q39105381-92EE98A9-A81C-4FEF-B79C-4BAD12326700 Q39137494-DD7CD88B-0BDC-43BE-A6DB-8BBCE39344B8 Q39398933-8B79308D-5868-43A9-99D4-00838B9B78CA Q40132104-CFDDB929-2F2A-4B26-8FED-B4A5AA0359D3 Q40153668-33548AC4-E43D-4AB8-8DC2-60DD66277E40 Q40411907-5A17BA6F-C77C-43AC-874A-A47135132873 Q40555960-E07BDA2C-DD1E-4F65-B1A5-608D8214E798 Q42366610-69950BDA-AFC5-49DA-8A23-617A335FA3BA Q43126056-E5BB52F8-CFBF-4F9B-931C-97CDE10573E7

P2860

The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury.

http://www.wikidata.org/entity/Q36179559

description

2014 nî lūn-bûn

@nan

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

2014年论文

@zh

2014年论文

@zh-cn

name

The B-Raf(V600E) inhibitor dab ...... minophen-induced liver injury.

@ast

The B-Raf(V600E) inhibitor dab ...... minophen-induced liver injury.

@en

type

label

The B-Raf(V600E) inhibitor dab ...... minophen-induced liver injury.

@ast

The B-Raf(V600E) inhibitor dab ...... minophen-induced liver injury.

@en

prefLabel

The B-Raf(V600E) inhibitor dab ...... minophen-induced liver injury.

@ast

The B-Raf(V600E) inhibitor dab ...... minophen-induced liver injury.

@en

P1433

Q36179559-6A9AF98C-60CA-4DF9-8FEC-97B9FA20754D

P1476

Q36179559-634780B9-24A6-451B-B910-7DD6162D2B6B

P2093

Q36179559-018CFC2D-84D7-4728-BC4D-BD9488F136DC

Q36179559-0D427FB6-518D-4264-B5A4-BC1245B3FBE4

Q36179559-0D6B24FD-2FCD-45BD-A092-7F10041F1D7B

Q36179559-115A0272-1051-44C8-8013-97C98BFB9129

Q36179559-19429809-44E7-47B7-9297-7C5333DDFB56

Q36179559-5A7B61E5-76D0-4C99-87EF-A8AA9ECBD9B4

Q36179559-936DB8B8-96D3-42A0-8BEF-CBFBA571900F

Q36179559-B001EF4C-E8FE-47C2-A4D1-E0703490CB1D

Q36179559-B631B247-C703-47FD-9862-FF70031ED0B7

Q36179559-DE759199-8558-4474-9DC4-200DC7F0676A

P2860

Q36179559-048A39EC-2A21-47BD-9BFF-9B8B768742F3

Q36179559-053AEA5D-BF39-4D37-9428-DEC8A61C400F

Q36179559-1130BDB1-E241-49E9-8A36-6EEE5725CC15

Q36179559-14C79087-657F-41B6-A607-69370AB31975

Q36179559-16811013-2B05-4397-AAF8-0D0187951DCD

Q36179559-189D39E6-8D82-46FB-9BED-608AAD85BB77

Q36179559-202A79C7-6F1F-49C7-B879-D3230FA6EF49

Q36179559-214E5BC6-3269-48BC-ADD5-28969F50F269

Q36179559-30309704-7691-4083-93E1-29347A8CAFE5

Q36179559-32653AFA-BE41-41D2-85DF-0CB8395325AD

P304

Q36179559-C938F3F7-4D74-4339-9DDB-D71CCA0C5523

P31

Q36179559-8FFCE907-8F47-4E15-AA81-1195EFA6CA6A

P356

Q36179559-A3F2BA83-FC3B-4E01-AC52-1B06051D4511

P478

Q36179559-037616C6-3B32-4173-AB05-94C82DFC8148

P577

Q36179559-913ADDEE-9AC9-4AD9-B27C-7DE2680B1F80

P5875

Q36179559-3B43E7D4-A6FE-446B-A85E-1F33E5CC99AB

P698

Q36179559-65730AF4-1517-4C78-8C9C-AFC39759A2A1

P932

Q36179559-3D478712-6338-471A-974F-B313F935CD0F

P356

P1433

Cell Death and Disease

P1476

The B-Raf(V600E) inhibitor dab ...... minophen-induced liver injury.

@en

P2093

B Xiong

http://www.w3.org/2001/XMLSchema#string

C-H Yang

http://www.w3.org/2001/XMLSchema#string

J Ding

http://www.w3.org/2001/XMLSchema#string

J-M Feng

http://www.w3.org/2001/XMLSchema#string

J-X Li

http://www.w3.org/2001/XMLSchema#string

X-H Li

http://www.w3.org/2001/XMLSchema#string

X-X Chen

http://www.w3.org/2001/XMLSchema#string

Y Chen

http://www.w3.org/2001/XMLSchema#string

Y Su

http://www.w3.org/2001/XMLSchema#string

Y Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Causes and outcomes of acute liver failure in China

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

Structural basis of RIP1 inhibition by necrostatins

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Ipilimumab, vemurafenib, dabrafenib, and trametinib: synergistic competitors in the clinical management of BRAF mutant malignant melanoma

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

P304

e1278

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/CDDIS.2014.241

http://www.w3.org/2001/XMLSchema#string

P478

5

http://www.w3.org/2001/XMLSchema#string

P577

2014-06-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

262882994

http://www.w3.org/2001/XMLSchema#string

P698

24901049

http://www.w3.org/2001/XMLSchema#string

P932

4611716

http://www.w3.org/2001/XMLSchema#string