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A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acidsThrombin inhibition by the serpinsRecombinant thrombomodulin protects mice against histone-induced lethal thromboembolismMolecular basis of thrombomodulin activation of slow thrombinCrystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin InhibitorsCrystal structure of the prothrombinase complex from the venom of Pseudonaja textilisGpIbα Interacts Exclusively with Exosite II of ThrombinDiscovery and characterization of an antibody directed against exosite I of thrombinTargeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effectsDesigning Allosteric Regulators of Thrombin. Exosite 2 Features Multiple Subsites That Can Be Targeted by Sulfated Small Molecules for Inducing InhibitionFurther characterization of ADAMTS-13 inactivation by thrombin.Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites.How Na+ activates thrombin--a review of the functional and structural data.Recurrence of Thrombin-Injected Pseudoaneurysms Under Ultrasound Guidance: A 10-Year Retrospective Analysis.Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model.Regulation of the protein C anticoagulant and antiinflammatory pathways.Platelets and their chemokines in atherosclerosis-clinical applications.NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.The extended cleavage specificity of human thrombin.The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patientsThrombin inhibition by serpins disrupts exosite IISolution-phase vs surface-phase aptamer-protein affinity from a label-free kinetic biosensorA multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.Role of Factor XII in hemostasis and thrombosis: clinical implications.Switching cation-binding loops paves the way for redesigning allosteric activationIs thrombin a key player in the 'coagulation-atherogenesis' maze?Risk factors for venous and arterial thrombosisThe ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.Continuing education course #2: current understanding of hemostasis.Hyaluronic acid and thrombin upregulate MT1-MMP through PI3K and Rac-1 signaling and prime the homing-related responses of cord blood hematopoietic stem/progenitor cellsBench-to-bedside review: circulating microparticles--a new player in sepsis?Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombinMore than just one: multiplicity of Hirudins and Hirudin-like Factors in the Medicinal Leech, Hirudo medicinalis.Identification of exosite residues of factor Xa involved in recognition of PAR-2 on endothelial cellsDesign and characterization of an APC-specific serpin for the treatment of hemophilia.Meizothrombin is an unexpectedly zymogen-like variant of thrombin.A case of severe pulmonary thromboembolism in a young male with klinefelter syndromeLigand binding to anion-binding exosites regulates conformational properties of thrombin.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Directing thrombin.
@ast
Directing thrombin.
@en
type
label
Directing thrombin.
@ast
Directing thrombin.
@en
prefLabel
Directing thrombin.
@ast
Directing thrombin.
@en
P2093
P1433
P1476
Directing thrombin.
@en
P2093
David A Lane
Helen Philippou
James A Huntington
P304
P356
10.1182/BLOOD-2005-04-1710
P407
P577
2005-06-30T00:00:00Z