Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling.
about
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of Krüppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylationInsulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration.The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer.Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.Molecular biology of head and neck cancer: risks and pathways.Targeting the IGF-1R signaling and mechanisms for epigenetic gene silencing in human multiple myelomaPromising new molecular targeted therapies in head and neck cancer.Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.
P2860
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P2860
Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
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2005年论文
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name
Treatment of hematologic malig ...... biting IGF receptor signaling.
@ast
Treatment of hematologic malig ...... biting IGF receptor signaling.
@en
type
label
Treatment of hematologic malig ...... biting IGF receptor signaling.
@ast
Treatment of hematologic malig ...... biting IGF receptor signaling.
@en
prefLabel
Treatment of hematologic malig ...... biting IGF receptor signaling.
@ast
Treatment of hematologic malig ...... biting IGF receptor signaling.
@en
P2860
P356
P1476
Treatment of hematologic malig ...... biting IGF receptor signaling.
@en
P2093
Constantine S Mitsiades
Nicholas Mitsiades
P2860
P304
P356
10.1586/14737140.5.3.487
P577
2005-06-01T00:00:00Z