Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance - Wikidata - wikimedia - TriplyDB

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

http://www.wikidata.org/entity/Q36188464

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Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor Leptin: in search of role(s) in human physiology and pathophysiology.Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice The future of leptin and leptin analogues in the treatment of obesity.Induction of leptin resistance by activation of cAMP-Epac signaling.Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes.Effects of detraining on motor unit potential area, muscle function and physical performance based on CNTF gene polymorphism.Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity.The gp130 receptor cytokine family: regulators of adipocyte development and function.The therapeutic potential of interleukin-6 in treating obesity.Emerging antiobesity drugs.Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity gp130 receptor ligands as potential therapeutic targets for obesity.Peptides and their potential role in the treatment of diabetes and obesity.Circumventing leptin resistance for weight control The anorectic effect of CNTF does not require action in leptin-responsive neurons.Advances in anti-obesity therapeutics.Gene therapy for obesity.Central regulation of energy balance: inputs, outputs and leptin resistance.Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo.Central regulation of metabolism by protein tyrosine phosphatases Investigational therapies in the treatment of obesity.Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes.Neurotrophism and energy homeostasis: perfect together.The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells.The role of interleukin-6 in insulin resistance, body fat distribution and energy balance.Neurotrophic factor control of satiety and body weight.Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity.Oncostatin m is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes.Hypothalamic dysfunction in obesity.Molecular pathways linking metabolic inflammation and thermogenesis.Constitutive activation of STAT-3 and downregulation of SOCS-3 expression induced by adrenalectomy.Oncostatin m modulation of lipid storage.Expression of functional ciliary neurotrophic factor receptors in immortalized gonadotrophin-releasing hormone-secreting neurones.Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.Leptin receptor-mediated regulation of cholinergic neurotransmitter phenotype in cells of central nervous system origin.Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo.

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Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

http://www.wikidata.org/entity/Q36188464

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1997年论文

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1997年论文

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P2860

Positional cloning of the mouse obese gene and its human homologue

Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors

A null mutation in the human CNTF gene is not causally related to neurological diseases

Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides

Interleukin-6 family of cytokines and gp130

The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

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