Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. - Wikidata - wikimedia - TriplyDB

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

http://www.wikidata.org/entity/Q36190713

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Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?Involvement of microRNA in microglia-mediated immune response Ly6 family proteins in neutrophil biology The involvement of microRNAs in neurodegenerative diseases Neuronal dark matter: the emerging role of microRNAs in neurodegeneration Inflammatory monocytes and the pathogenesis of viral encephalitis Microglia centered pathogenesis in ALS: insights in cell interconnectivity M1 and M2 immune activation in Parkinson's Disease: Foe and ally?Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.Circulating microRNAs as biomarkers for disease staging in multiple sclerosis Identification of a unique TGF-β-dependent molecular and functional signature in microglia Therapeutic inflammatory monocyte modulation using immune-modifying microparticles Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms.Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage.Evidence for an early innate immune response in the motor cortex of ALS.NP001 regulation of macrophage activation markers in ALS: a phase I clinical and biomarker study Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis Ontogeny and functions of central nervous system macrophages.Microglial phenotype and adaptation.Inflammatory dysregulation of blood monocytes in Parkinson's disease patients.Microglia: unique and common features with other tissue macrophages.Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis.Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis.Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS.Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions P2Y12 expression and function in alternatively activated human microglia.Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice.Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis.Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma.Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis.

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Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

http://www.wikidata.org/entity/Q36190713

description

2012 nî lūn-bûn

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name

Modulating inflammatory monocy ...... nature ameliorates murine ALS.

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Modulating inflammatory monocy ...... nature ameliorates murine ALS.

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Modulating inflammatory monocy ...... nature ameliorates murine ALS.

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Modulating inflammatory monocy ...... nature ameliorates murine ALS.

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Modulating inflammatory monocy ...... nature ameliorates murine ALS.

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Modulating inflammatory monocy ...... nature ameliorates murine ALS.

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Journal of Clinical Investigation

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Modulating inflammatory monocy ...... gnature ameliorates murine ALS

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Amanda J Lanser

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Anna M Krichevsky

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Ben Dake

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Camille E Doykan

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Galina Gabriely

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Gopal Murugaiyan

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James Berry

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Oleg Butovsky

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Pauline M Wu

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Reddy R Gali

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P2860

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators

Proinflammatory role for let-7 microRNAS in experimental asthma

MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development

Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells

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3063-3087

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10.1172/JCI62636

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9

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122

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Howard L. Weiner

Lakshmanan K Iyer

Merit E Cudkowicz

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2012-08-06T00:00:00Z

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230618697

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22863620

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amyotrophic lateral sclerosis

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3428086

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