TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study.
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Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesLarge-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesPolymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic RTCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention programNo association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.TCF7L2 is a master regulator of insulin production and processing.rs7903146 polymorphism at transcription factor 7 like 2 gene is associated with total cholesterol and lipoprotein profile in HIV/hepatitis C virus-coinfected patients.No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African AmericansAssociation of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.Tissue-specific alternative splicing of TCF7L2.Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine.Role of the single nucleotide polymorphism rs7903146 of TCF7L2 in inducing nonsense-mediated decay.Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population.Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study.Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion.Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes.TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity.
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P2860
TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study.
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2009 nî lūn-bûn
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2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
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2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
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2009年论文
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name
TCF7L2 variants are associated ...... in the Framingham Heart Study.
@ast
TCF7L2 variants are associated ...... in the Framingham Heart Study.
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type
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TCF7L2 variants are associated ...... in the Framingham Heart Study.
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TCF7L2 variants are associated ...... in the Framingham Heart Study.
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TCF7L2 variants are associated ...... in the Framingham Heart Study.
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TCF7L2 variants are associated ...... in the Framingham Heart Study.
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P2093
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TCF7L2 variants are associated ...... in the Framingham Heart Study.
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A K Manning
E S Stolerman
J B McAteer
J C Florez
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P2888
P304
P356
10.1007/S00125-009-1266-2
P577
2009-01-31T00:00:00Z