Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs. - Wikidata - wikimedia - TriplyDB

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

http://www.wikidata.org/entity/Q36209145

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Repurposing metformin: an old drug with new tricks in its binding pockets Serine, glycine and one-carbon units: cancer metabolism in full circle MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents Application of artificial neural networks to investigate one-carbon metabolism in Alzheimer's disease and healthy matched individuals Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells Metformin Improves Diabetic Bone Health by Re-Balancing Catabolism and Nitrogen Disposal Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.Metformin-induced metabolic reprogramming of chemoresistant ALDHbright breast cancer cells Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways Metformin limits the tumourigenicity of iPS cells without affecting their pluripotency.Metformin for cancer and aging prevention: is it a time to make the long story short?Metformin may reduce oral cancer risk in patients with type 2 diabetes High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model.One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin Potential applications for biguanides in oncology A marriage of two "Methusalem" drugs for the treatment of psoriasis?: Arguments for a pilot trial with metformin as add-on for methotrexate.Metformin reduces gastric cancer risk in patients with type 2 diabetes mellitus.Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport Metformin use and cervical cancer risk in female patients with type 2 diabetes Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.Metformin and esophageal cancer risk in Taiwanese patients with type 2 diabetes mellitus.The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.Mitochondrial dysfunction: a basic mechanism in inflammation-related non-communicable diseases and therapeutic opportunities.Expanding the therapeutic spectrum of metformin: from diabetes to cancer.Combined transcriptome and metabolome analyses of metformin effects reveal novel links between metabolic networks in steroidogenic systems.A Structural Basis for Biguanide Activity.Metformin use in pregnancy: promises and uncertainties.Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.Metabolic heterogeneity signature of primary treatment-naïve prostate cancer.Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration.Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme.One-Carbon Metabolism in Health and Disease.Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile.Oncobiguanides: Paracelsus' law and nonconventional routes for administering diabetobiguanides for cancer treatment.Recent advances in the use of metformin: can treating diabetes prevent breast cancer?Metformin and lung cancer risk in patients with type 2 diabetes mellitus.

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Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

http://www.wikidata.org/entity/Q36209145

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2012 nî lūn-bûn

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Metabolomic fingerprint reveal ...... e class of chemotherapy drugs.

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Metabolomic fingerprint reveal ...... e class of chemotherapy drugs.

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Metabolomic fingerprint reveal ...... e class of chemotherapy drugs.

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Alejandro Vazquez-Martin

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Antonio Segura-Carretero

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Bruna Corominas-Faja

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Cristina Oliveras-Ferraros

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Javier A Menendez

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Jorge Joven

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Rosa Quirantes-Piné

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Sílvia Cufí

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Vicente Micol

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P2860

Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

Folic Acid for the Prevention of Colorectal Adenomas

Metformin activates AMP kinase through inhibition of AMP deaminase

Brick by brick: metabolism and tumor cell growth

Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Anticancer antifolates: current status and future directions

Folate and cancer--timing is everything

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

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480-498

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10.18632/AGING.100472

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7

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4

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Begoña Martin-Castillo

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2012-07-01T00:00:00Z

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22837425

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