Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: relations between the biosynthetic events in the ER and solution behaviors in vitro.
about
Advances in recombinant antibody manufacturingMitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineeringIntermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum.Strategies and Considerations for Improving Expression of "Difficult to Express" Proteins in CHO Cells.Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.Overexpression of cryoglobulin-like single-chain antibody induces morular cell phenotype via liquid-liquid phase separation in the secretory pathway organelles.
P2860
Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: relations between the biosynthetic events in the ER and solution behaviors in vitro.
description
2014 nî lūn-bûn
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2014年の論文
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name
Russell body phenotype is pref ...... d solution behaviors in vitro.
@ast
Russell body phenotype is pref ...... d solution behaviors in vitro.
@en
type
label
Russell body phenotype is pref ...... d solution behaviors in vitro.
@ast
Russell body phenotype is pref ...... d solution behaviors in vitro.
@en
prefLabel
Russell body phenotype is pref ...... d solution behaviors in vitro.
@ast
Russell body phenotype is pref ...... d solution behaviors in vitro.
@en
P2093
P2860
P356
P1476
Russell body phenotype is pref ...... d solution behaviors in vitro.
@en
P2093
Ai Ching Lim
Christopher E Woods
Francis Kinderman
Haruki Hasegawa
P2860
P304
P356
10.4161/MABS.36242
P577
2014-01-01T00:00:00Z