Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestins
about
Analyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsVisualization of arrestin recruitment by a G-protein-coupled receptorHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesIdentification of receptor binding-induced conformational changes in non-visual arrestins.G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.Engineering visual arrestin-1 with special functional characteristicsA G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.The β-Arrestins: Multifunctional Regulators of G Protein-coupled ReceptorsConstitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 bindingFunctional map of arrestin-1 at single amino acid resolutionStructural determinants of arrestin functionsExtensive shape shifting underlies functional versatility of arrestins.Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes.Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypesThe Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling.Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex.Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors.Targeting individual GPCRs with redesigned nonvisual arrestins.Self-association of arrestin family members.Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.Therapeutic potential of small molecules and engineered proteins.Arrestin-dependent activation of JNK family kinasesEnhanced phosphorylation-independent arrestins and gene therapy.Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors.Molecular Mechanisms of GPCR Signaling: A Structural Perspective.Structure and dynamics of GPCR signaling complexes.
P2860
Q26785358-74F54E46-0FFE-4DA6-BF11-B9994A734EC2Q28244290-C67C0D72-229C-4D21-9C16-3539B71F4A79Q28646207-148F7566-E93B-464E-A3AE-E50E4BDC04C3Q33947214-A2F2DCF9-3060-4D3E-AE17-238F4406C170Q35536256-FA7B2553-CC3D-48F1-AC2C-C53D4B5C3BC4Q35600398-24A582BB-051E-4E45-BD14-125779F0C78FQ35830953-1C907A50-725F-4728-9155-31DE9354392FQ36579557-1F50BD54-CE51-4961-88D3-AEACC4C4F9D2Q36778728-F28555E0-2E0D-4A04-849F-DEF3E2BE2202Q36796795-495C1362-5048-4405-9C6B-90024DAD4769Q36884777-F10F959B-25C1-4106-BF26-D46AC0768A6AQ37174339-C7E7F48F-58BA-41C1-BB82-2BCEB3311AAAQ37571225-A76077BB-7195-44B3-B361-9FE599FC81BCQ38114211-E4463626-AA14-4F80-B965-4066C99562A4Q38200331-7B050FEA-C257-40B9-BDBC-E998607D653CQ38690634-A67C9CFE-7675-45BE-AE16-3C2EE9BF9CDAQ39009770-BEA28F06-5A4C-4D3E-AD00-BC822D9E8FBDQ39381430-45268980-01CD-4821-B42A-905AAABEC7B1Q40883348-029ED7AB-F736-4264-8DD6-B0D9ACFE2BBEQ41836899-B043C0C7-67A7-46A3-AC4B-BD22BA9382C0Q41872788-AB8234A2-93D8-4656-B43F-4882097CC7D4Q41965656-50D43D06-9791-4969-ABFC-A0EDDDAE222BQ42044999-903E5F8C-F772-42D6-9DCE-585EEDEC16A5Q42098997-3A073736-AA19-4DFF-9625-4CC9FAA3BCC2Q42385786-0F17748B-65A3-4185-BC3E-6FE053579AC7Q42394084-5D54DCB5-2132-431F-9655-809670877CA8Q42509112-47DC69D7-0A39-47D5-8391-4EC3D6854ADDQ47255137-8DD9E2C2-A3BC-4754-A652-A33E0BE0C38DQ50093625-1DF0A302-2BF7-4144-87E2-C1C923974C44
P2860
Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestins
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Manipulation of very few recep ...... ficity of non-visual arrestins
@ast
Manipulation of very few recep ...... ficity of non-visual arrestins
@en
type
label
Manipulation of very few recep ...... ficity of non-visual arrestins
@ast
Manipulation of very few recep ...... ficity of non-visual arrestins
@en
prefLabel
Manipulation of very few recep ...... ficity of non-visual arrestins
@ast
Manipulation of very few recep ...... ficity of non-visual arrestins
@en
P2093
P2860
P356
P1476
Manipulation of very few recep ...... ficity of non-visual arrestins
@en
P2093
Faiza Baameur
Luis E Gimenez
Sergey A Vishnivetskiy
P2860
P304
29495-29505
P356
10.1074/JBC.M112.366674
P407
P577
2012-07-11T00:00:00Z