Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.
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Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.Glucose Enhances Basal or Melanocortin-Induced cAMP-Response Element Activity in Hypothalamic Cells.SNAP: predict effect of non-synonymous polymorphisms on function.ROHHAD Syndrome: Reasons for Diagnostic Difficulties in Obesity.In silico mutagenesis: a case study of the melanocortin 4 receptorClinically relevant known and candidate genes for obesity and their overlap with human infertility and reproduction.The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Unifying view of mechanical and functional hotspots across class A GPCRs.Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targetsAllelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study groupMechanisms of disease: Mutations of G proteins and G-protein-coupled receptors in endocrine diseases.Satiety and the Self-Regulation of Food Take in Children: a Potential Role for Gene-Environment Interplay.Implications of gene-behavior interactions: prevention and intervention for obesity.Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review.Making sense of metabolic obesity and hedonic obesity.Melanocortin-induced PKA activation inhibits AMPK activity via ERK-1/2 and LKB-1 in hypothalamic GT1-7 cells.Pertussis toxin-sensitive signaling of melanocortin-4 receptors in hypothalamic GT1-7 cells defines agouti-related protein as a biased agonist.Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy.Associations between single nucleotide polymorphisms in 33 candidate genes and meat quality traits in commercial pigs.Association between melanocortin-4 receptor mutations and eating behaviors in obese patients: a case--control study.Identification of biomarkers for childhood obesity based on expressional correlation and functional similarity.Pharmacological Chaperones: Potential for the Treatment of Hereditary Diseases Caused by Mutations in G Protein-Coupled ReceptorsMelanocortin-4 Receptor Gene Mutations in a Dutch Cohort of Obese Children
P2860
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P2860
Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
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2005年论文
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2005年论文
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name
Obesity-associated mutations i ...... el insights into its function.
@ast
Obesity-associated mutations i ...... el insights into its function.
@en
type
label
Obesity-associated mutations i ...... el insights into its function.
@ast
Obesity-associated mutations i ...... el insights into its function.
@en
prefLabel
Obesity-associated mutations i ...... el insights into its function.
@ast
Obesity-associated mutations i ...... el insights into its function.
@en
P2093
P1433
P1476
Obesity-associated mutations i ...... el insights into its function.
@en
P2093
Astrid Shapiro
Cecile Lubrano-Berthelier
Cedric Govaerts
Christian Vaisse
Franck Picard
Karine Clement
Sumei Zhang
Supriya Srinivasan
P304
P356
10.1016/J.PEPTIDES.2004.11.042
P577
2005-10-01T00:00:00Z