Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome. - Wikidata - wikimedia - TriplyDB

Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.

Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.

http://www.wikidata.org/entity/Q36220166

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Facioscapulohumeral dystrophy: the path to consensus on pathophysiology The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation The "lnc" between 3D chromatin structure and X chromosome inactivation Xist localization and function: new insights from multiple levels X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells Dosage compensation of the sex chromosomes Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes The FSHD2 Gene SMCHD1 Is a Modifier of Disease Severity in Families Affected by FSHD1 Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2 De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development.Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.Epigenetic characterization of the growth hormone gene identifies SmcHD1 as a regulator of autosomal gene clusters.An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation.X chromosome regulation: diverse patterns in development, tissues and disease.Variable escape from X-chromosome inactivation: identifying factors that tip the scales towards expression Genomic insights into cancer-associated aberrant CpG island hypermethylation Identification of two novel SMCHD1 sequence variants in families with FSHD-like muscular dystrophy.X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse.SMCHD1 accumulates at DNA damage sites and facilitates the repair of DNA double-strand breaks Dosage compensation in mammals.Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy.Facioscapulohumeral muscular dystrophy as a model for epigenetic regulation and disease Genetic and epigenetic characteristics of FSHD-associated 4q and 10q D4Z4 that are distinct from non-4q/10q D4Z4 homologs Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells.Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST.Segregation between SMCHD1 mutation, D4Z4 hypomethylation and Facio-Scapulo-Humeral Dystrophy: a case report.A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2'-dC upon inhibition of ribonucleotide reductase.Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.Random X-chromosome inactivation dynamics in vivo by single-cell RNA sequencing.Genetic and epigenetic contributors to FSHD.X chromosome reactivation in reprogramming and in development Systems genetics implicates cytoskeletal genes in oocyte control of cloned embryo quality.Transcriptional profiling of the epigenetic regulator Smchd1.Double SMCHD1 variants in FSHD2: the synergistic effect of two SMCHD1 variants on D4Z4 hypomethylation and disease penetrance in FSHD2.X-chromosome inactivation and escape.Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing.

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P2860

Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.

http://www.wikidata.org/entity/Q36220166

description

2012 nî lūn-bûn

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2012年论文

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2012年论文

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2012年论文

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name

Smchd1-dependent and -independ ...... on the inactive X chromosome.

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Smchd1-dependent and -independ ...... on the inactive X chromosome.

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type

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Smchd1-dependent and -independ ...... on the inactive X chromosome.

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Smchd1-dependent and -independ ...... on the inactive X chromosome.

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prefLabel

Smchd1-dependent and -independ ...... on the inactive X chromosome.

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Smchd1-dependent and -independ ...... on the inactive X chromosome.

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Developmental Cell

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Anwyn Apedaile

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Ausma Termanis

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Derek Huntley

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Edith Heard

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P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure.

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

DNA methylation patterns and epigenetic memory

CpG islands recruit a histone H3 lysine 36 demethylase

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

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Irina Stancheva

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