Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction
about
Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin EA range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23IgE binds asymmetrically to its B cell receptor CD23Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies.General mechanism for modulating immunoglobulin effector function.Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.Immuno-evasive tactics by schistosomes identify an effective allergy preventative.Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.Serum from a subset of patients with chronic lymphocytic leukemia and large local reactions to mosquito bites induces upregulation of CD63 surface expression on basophils in atopic donors.
P2860
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P2860
Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
@zh-cn
name
Mapping of the CD23 binding si ...... e IgE-Fc epsilonRI interaction
@ast
Mapping of the CD23 binding si ...... e IgE-Fc epsilonRI interaction
@en
type
label
Mapping of the CD23 binding si ...... e IgE-Fc epsilonRI interaction
@ast
Mapping of the CD23 binding si ...... e IgE-Fc epsilonRI interaction
@en
prefLabel
Mapping of the CD23 binding si ...... e IgE-Fc epsilonRI interaction
@ast
Mapping of the CD23 binding si ...... e IgE-Fc epsilonRI interaction
@en
P2093
P2860
P356
P1476
Mapping of the CD23 binding si ...... e IgE-Fc epsilonRI interaction
@en
P2093
Alison M Cooper
Andrew J Beavil
Brian J Sutton
Hannah J Gould
Heather J Bax
James M McDonnell
Marie O Y Pang
Michael W Kao
Norhakim Yahya
Richard G Hibbert
P2860
P304
31457-31461
P356
10.1074/JBC.C112.397059
P407
P577
2012-07-19T00:00:00Z