Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.

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Emerging roles for long noncoding RNAs in skeletal biology and disease.The chemical evolution of oligonucleotide therapies of clinical utility.Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

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Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.

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2015 nî lūn-bûn

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Enhancing antisense efficacy w ...... MTOs) using cleavable linkers.

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Enhancing antisense efficacy w ...... MTOs) using cleavable linkers.

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Enhancing antisense efficacy w ...... MTOs) using cleavable linkers.

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Enhancing antisense efficacy w ...... MTOs) using cleavable linkers.

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Enhancing antisense efficacy w ...... MTOs) using cleavable linkers.

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P2093

Abhijit Bhat

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Arthur M Krieg

http://www.w3.org/2001/XMLSchema#string

Bing Kuang

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Eugen Uhlmann

http://www.w3.org/2001/XMLSchema#string

Kathleen M Ogilvie

http://www.w3.org/2001/XMLSchema#string

Mark A Wysk

http://www.w3.org/2001/XMLSchema#string

Markus Weber

http://www.w3.org/2001/XMLSchema#string

Thomas D Rockel

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P2860

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

LNA-mediated microRNA silencing in non-human primates

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

Chemical modification and design of anti-miRNA oligonucleotides.

RNA therapeutics: beyond RNA interference and antisense oligonucleotides.

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes.

Silencing of microRNA families by seed-targeting tiny LNAs

Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology.

Phosphorothioates, essential components of therapeutic oligonucleotides.

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scholarly article

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10.1093/NAR/GKV992

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English

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Romesh Subramanian

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2015-10-07T00:00:00Z

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282669333

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4627098

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Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.

about

P2860

P2860

Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers.

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