A checkpoint for autoreactivity in human IgM+ memory B cell development
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IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humansCD20 deficiency in humans results in impaired T cell-independent antibody responsesResolve, revise, and relax: the 3 Rs of B cell repertoire adjustmentImmunological aspects in chronic lymphocytic leukemia (CLL) developmentClonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemiaAiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesCrossing the Atlantic: the Euro-Lupus Nephritis regimen in North AmericaHigh-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations.Construction of a large naïve human phage-displayed Fab library through one-step cloning.Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosusDevelopment of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh.Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties.The role of B cells in lupus pathogenesis.Autoreactive marginal zone B cells enter the follicles and interact with CD4+ T cells in lupus-prone mice.The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpointsBasophils and the T helper 2 environment can promote the development of lupus nephritis.Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients.B-cell-lineage immunogen design in vaccine development with HIV-1 as a case studyMarginal zone B cells: virtues of innate-like antibody-producing lymphocytes.Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodiesMature B cells class switched to IgD are autoreactive in healthy individualsA fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favorable biophysical properties.Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's syndrome.The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific.Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.Autoantibodies: Focus on anti-DNA antibodies.The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humansInitial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutatedDifferential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells.Antibody engineering for increased potency, breadth and half-life.B cells and autoimmunity.Autoreactivity in human IgG+ memory B cells.Phenotypic analysis of pneumococcal polysaccharide-specific B cells.Immune Responses to pneumococcal vaccines in children and adults: Rationale for age-specific vaccination.Exploiting human memory B cell heterogeneity for improved vaccine efficacy.Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapyDevelopmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8Chronic hepatitis C virus infection breaks tolerance and drives polyclonal expansion of autoreactive B cells.Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs
P2860
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P2860
A checkpoint for autoreactivity in human IgM+ memory B cell development
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A checkpoint for autoreactivity in human IgM+ memory B cell development
@ast
A checkpoint for autoreactivity in human IgM+ memory B cell development
@en
type
label
A checkpoint for autoreactivity in human IgM+ memory B cell development
@ast
A checkpoint for autoreactivity in human IgM+ memory B cell development
@en
prefLabel
A checkpoint for autoreactivity in human IgM+ memory B cell development
@ast
A checkpoint for autoreactivity in human IgM+ memory B cell development
@en
P2093
P2860
P356
P1476
A checkpoint for autoreactivity in human IgM+ memory B cell development
@en
P2093
Hedda Wardemann
Klara Velinzon
Saskia Thomas
Sergey Yurasov
P2860
P304
P356
10.1084/JEM.20052033
P407
P577
2006-01-30T00:00:00Z