Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics.
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Role of pregnane X receptor in chemotherapeutic treatmentHuman pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activityCytochrome P450-mediated drug metabolism in the brainExplaining variability in ciclosporin exposure in adult kidney transplant recipients.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium FerulateCYP2B6: new insights into a historically overlooked cytochrome P450 isozymeDifferential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirineMulti-species analyses of direct activators of the constitutive androstane receptor.Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugsExploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in MalawiansFunctional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" ProblemTryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspectivePharmacogenetics of the constitutive androstane receptor.Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism.Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analoguesOxazaphosphorine bioactivation and detoxification The role of xenobiotic receptors.The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy.Genetic Polymorphisms Contribute to the Individual Variations of Imatinib Mesylate Plasma Levels and Adverse Reactions in Chinese GIST Patients.Nuclear receptor PXR, transcriptional circuits and metabolic relevance.Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics.The Effect of Gene Variants on Levonorgestrel Pharmacokinetics When Combined With Antiretroviral Therapy Containing Efavirenz or Nevirapine.The potential of steroids and xenobiotic receptor polymorphisms in forecasting cyclosporine pharmacokinetic variability in young kidney transplant recipients.Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses.Individualized immunosuppression in transplant patients: potential role of pharmacogenetics.Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers.Pharmacogenetics of nevirapine excretion into breast milk and infants' exposure through breast milk versus postexposure prophylaxis.Systematic target function annotation of human transcription factors.Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients.PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients.Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer.SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome.Biological and genetic factors associated with ABCB1 and pregnane-X-receptor expressions in peripheral blood mononuclear cells in the STANISLAS cohort.
P2860
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P2860
Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Genetic variants of PXR (NR1I2 ...... tabolism and pharmacogenetics.
@ast
Genetic variants of PXR (NR1I2 ...... tabolism and pharmacogenetics.
@en
type
label
Genetic variants of PXR (NR1I2 ...... tabolism and pharmacogenetics.
@ast
Genetic variants of PXR (NR1I2 ...... tabolism and pharmacogenetics.
@en
prefLabel
Genetic variants of PXR (NR1I2 ...... tabolism and pharmacogenetics.
@ast
Genetic variants of PXR (NR1I2 ...... tabolism and pharmacogenetics.
@en
P2093
P356
P1476
Genetic variants of PXR (NR1I2 ...... tabolism and pharmacogenetics.
@en
P2093
Erin Schuetz
Jatinder Lamba
Vishal Lamba
P304
P356
10.2174/1389200054633880
P407
P577
2005-08-01T00:00:00Z