Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin.
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Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interactionIntegrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formationDifferential regulation of alpha 4 integrin-dependent binding to domains 1 and 4 of vascular cell adhesion molecule-1Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseasesHigh-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding.The pathophysiologic role of alpha 4 integrins in vivoMicromechanical tests of adhesion dynamics between neutrophils and immobilized ICAM-1Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectinThe interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain.Integrins, cations and ligands: making the connection.The regulation of integrin function by divalent cations.Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1Modulation of in vivo migratory function of alpha 2 beta 1 integrin in mouse liverDefining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand bindingAdhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects.Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits.Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins.CD49d expression and function on allergen-stimulated T cells from blood and airway.Aspartate 698 within a novel cation binding motif in alpha 4 integrin is required for cell adhesion.Integrin beta1-chain residues involved in substrate recognition and specificity of binding to invasin.Ligand binding and affinity modulation of integrins.Differential effects of integrin alpha chain mutations on invasin and natural ligand interaction.A region of the Yersinia pseudotuberculosis invasin protein that contributes to high affinity binding to integrin receptors.A novel region of the alpha4 integrin subunit with a modulatory role in VLA-4-mediated cell adhesion to fibronectin.Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin.Silencing of TLR4 increases tumor progression and lung metastasis in a murine model of breast cancer.Macrophage response to microbial pathogens: modulation of the expression of adhesion, CD14, and MHC class II molecules by viruses, bacteria, protozoa and fungi.Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands.Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).Increased synovial endothelium binding and transendothelial migration of mononuclear cells during Salmonella infection.Modulation of peripheral blood mononuclear cell activation status during Salmonella-triggered reactive arthritis.A Secondary Structure Model of the Integrin a Subunit N-Terminal Domain Based on Analysis of Multiple Alignments
P2860
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P2860
Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Mutation of putative divalent ...... ronectin, VCAM-1, and invasin.
@ast
Mutation of putative divalent ...... ronectin, VCAM-1, and invasin.
@en
type
label
Mutation of putative divalent ...... ronectin, VCAM-1, and invasin.
@ast
Mutation of putative divalent ...... ronectin, VCAM-1, and invasin.
@en
prefLabel
Mutation of putative divalent ...... ronectin, VCAM-1, and invasin.
@ast
Mutation of putative divalent ...... ronectin, VCAM-1, and invasin.
@en
P2860
P356
P1476
Mutation of putative divalent ...... ronectin, VCAM-1, and invasin.
@en
P2093
A Masumoto
M E Hemler
P2860
P304
P356
10.1083/JCB.123.1.245
P407
P577
1993-10-01T00:00:00Z