Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin
about
Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesisThe N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosomeBinding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament bindingThree novel homozygous point mutations and a new polymorphism in the COL17A1 gene: relation to biological and clinical phenotypes of junctional epidermolysis bullosaHemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunitDemonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formationTwo forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomainBeta4 integrin is required for hemidesmosome formation, cell adhesion and cell survivalCaspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration.Collagen XVII and BPAG1 expression in the retina: evidence for an anchoring complex in the central nervous system.Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia.Collagenous transmembrane proteins: recent insights into biology and pathology.Immunodiagnosis of pemphigus and mucous membrane pemphigoid.Type XVII collagen regulates lamellipod stability, cell motility, and signaling to Rac1 by targeting bullous pemphigoid antigen 1e to alpha6beta4 integrinUsefulness of Enzyme-linked Immunosorbent Assay Using Recombinant BP180 and BP230 for Serodiagnosis and Monitoring Disease Activity of Bullous PemphigoidThe integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structuresCollagen XVII/BP180: a collagenous transmembrane protein and component of the dermoepidermal anchoring complex.Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesionsIdentification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls.Collagen XVII: a shared antigen in neurodermatological interactions?Molecular architecture and function of the hemidesmosome.Molecular architecture and function of the hemidesmosome.Intermediate Filaments and the Plasma Membrane.Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332.Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells.BP180 gene delivery in junctional epidermolysis bullosa.Molecular complexity of the cutaneous basement membrane zone. Revelations from the paradigms of epidermolysis bullosa.The integrin alpha 6 beta 4 and the biology of carcinoma.Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide.Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migrationStructural proteins of the dermal-epidermal junction targeted by autoantibodies in pemphigoid diseases.
P2860
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P2860
Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Molecular genetic studies of a ...... een BP180 and alpha 6 integrin
@ast
Molecular genetic studies of a ...... een BP180 and alpha 6 integrin
@en
type
label
Molecular genetic studies of a ...... een BP180 and alpha 6 integrin
@ast
Molecular genetic studies of a ...... een BP180 and alpha 6 integrin
@en
prefLabel
Molecular genetic studies of a ...... een BP180 and alpha 6 integrin
@ast
Molecular genetic studies of a ...... een BP180 and alpha 6 integrin
@en
P2093
P2860
P356
P1476
Molecular genetic studies of a ...... een BP180 and alpha 6 integrin
@en
P2093
S B Hopkinson
P2860
P304
P356
10.1083/JCB.130.1.117
P407
P577
1995-07-01T00:00:00Z