Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
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Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputsThe ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cellsAssociation of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population.Furin at the cutting edge: from protein traffic to embryogenesis and diseaseEngineering the gut for insulin replacement to treat diabetesIs GLP-1 a hormone: Whether and When?60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptidesMolecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes MellitusElusive liver factor that causes pancreatic α cell hyperplasia: A review of literatureAlpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?Reprogramming pancreatic cells to β cellsPhysiology of proglucagon peptides: role of glucagon and GLP-1 in health and diseaseCellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammalsRegulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoterIdentification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental studyLower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout miceDifferential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addictCathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expressionNeutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and developmentThe multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functionsInhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.Altered neuropeptide profile of Caenorhabditis elegans lacking the chaperone protein 7B2 as analyzed by mass spectrometry.Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic miceThe proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH.Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cellsInsulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.Deficiency of prohormone convertase dPC2 (AMONTILLADO) results in impaired production of bioactive neuropeptide hormones in Drosophila.Gut hormones, and short bowel syndrome: the enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation.Dynamic changes in proprotein convertase 2 activity in cortical neurons after ischemia/reperfusion and oxygen-glucose deprivationA look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family.Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice.Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis.What lies ahead for the proprotein convertases?Analysis of the proteolysis of bioactive peptides using a peptidomics approach.
P2860
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P2860
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Defective prohormone processin ...... y in mice lacking active SPC2.
@ast
Defective prohormone processin ...... y in mice lacking active SPC2.
@en
type
label
Defective prohormone processin ...... y in mice lacking active SPC2.
@ast
Defective prohormone processin ...... y in mice lacking active SPC2.
@en
prefLabel
Defective prohormone processin ...... y in mice lacking active SPC2.
@ast
Defective prohormone processin ...... y in mice lacking active SPC2.
@en
P2093
P2860
P356
P1476
Defective prohormone processin ...... y in mice lacking active SPC2.
@en
P2093
D F Steiner
M Ravazzola
P2860
P304
P356
10.1073/PNAS.94.13.6646
P407
P577
1997-06-01T00:00:00Z