PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. - Wikidata - wikimedia - TriplyDB

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

http://www.wikidata.org/entity/Q36244792

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Signaling in T cells - is anything the m(a)TOR with the picture(s)?The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors mTOR: An attractive therapeutic target for osteosarcoma?PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases SGK1: The Dark Side of PI3K Signaling.RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes.The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer.Therapeutic potential of mTOR inhibitors for targeting cancer stem cells.Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes.Targeting mTOR for the treatment of B cell malignancies.mTOR Signaling in Growth, Metabolism, and Disease.Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment.Molecular signaling cascades involved in nonmelanoma skin carcinogenesis.mTORC1 and mTORC2 in cancer and the tumor microenvironment.Unraveling the regulation of mTORC2 using logical modeling.m-TOR inhibitors and their potential role in haematological malignancies.PI3K signaling in cancer: beyond AKT.AKT/PKB Signaling: Navigating the Network.Role Played by Signalling Pathways in Overcoming BRAF Inhibitor Resistance in Melanoma.PI3K/Akt promotes feedforward mTORC2 activation through IKKα.The PI3K/Akt pathway: a critical player in intervertebral disc degeneration.Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.A central role for a region in the middle Localization of mTORC2 activity inside cells.mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.The SIN1-PH Domain Connects mTORC2 to PI3K.mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL.TOR-mediated regulation of metabolism in aging.Uncoupling TORC2 from AGC kinases inhibits tumour growth.Evolutionary Conservation of the Components in the TOR Signaling Pathways.The PI3K Pathway in Human Disease.TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance.

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

http://www.wikidata.org/entity/Q36244792

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

@zh-tw

2015年论文

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2015年论文

@zh

2015年论文

@zh-cn

name

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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type

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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prefLabel

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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2159-8290.CD-15-0460

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Cancer Discovery

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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

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Alex Toker

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Bin Wang

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Bing Su

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Jianping Guo

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Jinfang Zhang

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John Blenis

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Kohei Ogura

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Pengda Liu

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Wenjian Gan

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Wenyi Wei

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P2860

Activation of mTORC2 by association with the ribosome

Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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1194-1209

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11

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5

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Lewis C. Cantley

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2015-08-20T00:00:00Z

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281168999

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26293922

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4631654

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