Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. - Wikidata - wikimedia - TriplyDB

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.

http://www.wikidata.org/entity/Q36249529

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Immune Regulation and Antitumor Effect of TIM-1 Regulatory T Cells in Kidney Transplantation: New Directions?Treg functional stability and its responsiveness to the microenvironment TIM-1 signaling is required for maintenance and induction of regulatory B cells.Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory.Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells.Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma.Regulatory T-cell stability and plasticity in mucosal and systemic immune systems.Costimulatory pathways in transplantation.Sequence, structure, function, immunity: structural genomics of costimulation.Lineage stability and phenotypic plasticity of Foxp3⁺ regulatory T cells.Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells.Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.Th17 cells and transplant acceptance Tregs and infections: on the potential value of modifying their function.HAVCR1 gene haplotypes and infection by different viral hepatitis C virus genotypes Tuning microenvironments: induction of regulatory T cells by dendritic cells The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model.Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation.Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells TIM-1 and TIM-3 proteins in immune regulation.Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.The immune boundaries for stem cell based therapies: problems and prospective solutions.Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis.Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs The costimulatory role of TIM molecules.Tim-1-Fc suppresses chronic cardiac allograft rejection and vasculopathy by reducing IL-17 production T cell Ig and mucin domain proteins and immunity.TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.The emerging role of the TIM molecules in transplantation.Rejection and regulation: a tight balance.The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.Costimulation blockade: current perspectives and implications for therapy.

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P2860

Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.

http://www.wikidata.org/entity/Q36249529

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Immunostimulatory Tim-1-specif ...... transplant tolerance in mice.

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Immunostimulatory Tim-1-specif ...... transplant tolerance in mice.

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type

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Immunostimulatory Tim-1-specif ...... transplant tolerance in mice.

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Immunostimulatory Tim-1-specif ...... transplant tolerance in mice.

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prefLabel

Immunostimulatory Tim-1-specif ...... transplant tolerance in mice.

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Immunostimulatory Tim-1-specif ...... transplant tolerance in mice.

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P1433

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Journal of Clinical Investigation

P1476

Immunostimulatory Tim-1-specif ...... transplant tolerance in mice.

@en

P2093

Christophe Mariat

http://www.w3.org/2001/XMLSchema#string

Dale T Umetsu

http://www.w3.org/2001/XMLSchema#string

Dong Zhang

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James Kenny

http://www.w3.org/2001/XMLSchema#string

Minh Diem Vu

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Mohammed Oukka

http://www.w3.org/2001/XMLSchema#string

Nicolas Degauque

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Rosemarie H DeKruyff

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Sophoclis Alexopoulos

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Terry B Strom

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P2860

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Transforming growth factor-beta induces development of the T(H)17 lineage

TIM-1 induces T cell activation and inhibits the development of peripheral tolerance

TIM-1, a novel allergy and asthma susceptibility gene

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

A function for interleukin 2 in Foxp3-expressing regulatory T cells

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735-741

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10.1172/JCI32562

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2

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118

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5768555

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18079964

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2129234

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