Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides
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Growth inhibition and apoptosis induced by daunomycin-conjugated triplex-forming oligonucleotides targeting the c-myc gene in prostate cancer cellsSolution structure of a highly stable DNA duplex conjugated to a minor groove binderLinkage of a triple helix-forming oligonucleotide to amsacrine-4-carboxamide derivatives modulates the sequence-selectivity of topoisomerase II-mediated DNA cleavage.Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism.Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation.Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation.Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene.Oligo(alpha-deoxynucleotide)s covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestionUse of base modifications in primers and amplicons to improve nucleic acids detection in the real-time snake polymerase chain reaction.Efficient priming of PCR with short oligonucleotides conjugated to a minor groove binder.Oligonucleotides with conjugated dihydropyrroloindole tripeptides: base composition and backbone effects on hybridization.Extension of the range of DNA sequences available for triple helix formation: stabilization of mismatched triplexes by acridine-containing oligonucleotides.Oligo-[alpha]-deoxynucleotides covalently linked to an intercalating agent. Double helices with parallel strands are formed with complementary oligo-[beta]-deoxynucleotides.alpha-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural alpha-hexadeoxyribonucleotide alpha-[d(CpApTpGpCpG)] with its beta-complement beta-[d(GpTpApCpGpC)] deduced from high field 1H-NMR.Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-[alpha]-thymidylate covalently linked to an azidoproflavine derivativeSequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins.Selective inhibition of the cytopathic effect of type A influenza viruses by oligodeoxynucleotides covalently linked to an intercalating agentFluorescence energy transfer as a probe for nucleic acid structures and sequences.Oligothymidylates covalently linked to an acridine derivative and with modified phosphodiester backbone: circular dichroism studies of their interactions with complementary sequences.Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agentsInhibition of simian virus 40 DNA replication in CV-1 cells by an oligodeoxynucleotide covalently linked to an intercalating agent.Sequence-specific recognition of the major groove of DNA by oligodeoxynucleotides via triple helix formation. Footprinting studies.Rate of degradation of [alpha]- and [beta]-oligodeoxynucleotides in Xenopus oocytes. Implications for anti-messenger strategiesalpha-DNA-III. Characterization by high field 1H-NMR, anti-parallel self-recognition and conformation of the unnatural hexadeoxyribonucleotides alpha-[d(CpApTpGpCpG)] and alpha-[d(CpGpCpApTpG)]. Alpha-oligodeoxynucleotides as potential cellular probThe 1988 Walter Hubert lecture. Artificial control of gene expression by oligodeoxynucleotides covalently linked to intercalating agents.Replication of individual DNA molecules under electronic control using a protein nanopore.Antisense agents in cancer research and therapeutics.Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides.DNA sequencing by hybridization: 100 bases read by a non-gel-based method.Sequence-specific arrest of primer extension on single-stranded DNA by an oligonucleotide-minor groove binder conjugateNucleic acid-guided assembly of aromatic chromophores.Design, biochemical, biophysical and biological properties of cooperative antisense oligonucleotides.Invasion of strongly binding oligonucleotides into tRNA structure.Hybridization properties of deoxyoligonucleotides containing anthraquinone pseudonucleosides.A theoretical investigation of the base sequence preferences of monointercalating polymethylene carboxamide derivatives 9-aminoacridine.Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives.Conformations of duplex structures formed by oligodeoxynucleotides covalently linked to the intercalator 2-methoxy-6-chloro-9-aminoacridine.31P NMR studies of the binding of the oligonucleotide (Ap)3A to an oligodeoxythymidylate covalently linked to an acridine derivative.G/C-modified oligodeoxynucleotides with selective complementarity: synthesis and hybridization properties.
P2860
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P2860
Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
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1984年學術文章
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1984年學術文章
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name
Nucleic acid-binding molecules ...... inked to oligodeoxynucleotides
@ast
Nucleic acid-binding molecules ...... inked to oligodeoxynucleotides
@en
type
label
Nucleic acid-binding molecules ...... inked to oligodeoxynucleotides
@ast
Nucleic acid-binding molecules ...... inked to oligodeoxynucleotides
@en
prefLabel
Nucleic acid-binding molecules ...... inked to oligodeoxynucleotides
@ast
Nucleic acid-binding molecules ...... inked to oligodeoxynucleotides
@en
P2093
P2860
P356
P1476
Nucleic acid-binding molecules ...... inked to oligodeoxynucleotides
@en
P2093
Asseline U
Lancelot G
Montenay-Garestier T
P2860
P304
P356
10.1073/PNAS.81.11.3297
P407
P577
1984-06-01T00:00:00Z