Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes
about
An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cellsThe carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulumMitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activityIdentification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets.Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicityRoles of cytochrome p450 in development.Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol.NH2-terminal substitutions of basic amino acids induce translocation across the microsomal membrane and glycosylation of rabbit cytochrome P450IIC2.Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane.Transposition of domains between the M2 and HN viral membrane proteins results in polypeptides which can adopt more than one membrane orientationUnusual properties of the cytochrome P450 superfamily.Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge.Insertion of proteins into bacterial membranes: mechanism, characteristics, and comparisons with the eucaryotic process.Influence of protein-protein interactions on the cellular localization of cytochrome P450.Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptideCytochrome P-450 membrane signals.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Modifications in the N-terminus of an insect cytochrome P450 enhance production of catalytically active protein in baculovirus-Sf9 cell expression systems.Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1).Efficient assembly of functional cytochrome P450 2C2 requires a spacer sequence between the N-terminal signal anchor and catalytic domains.Post-translational transport of proteins into microsomal membranes of Candida maltosa.The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane.A short amino-terminal segment of microsomal cytochrome P-450 functions both as an insertion signal and as a stop-transfer sequence.A tripartite structure of the signals that determine protein insertion into the endoplasmic reticulum membrane.In vitro membrane assembly of a polytopic, transmembrane protein results in an enzymatically active conformationCharacterization of the signal that directs Tom20 to the mitochondrial outer membrane.On the solvent accessibility of substrate binding site of cytochrome P450C-21 in bovine adrenocortical microsomes.Biosynthetic Machinery of Diterpene Pleuromutilin Isolated from Basidiomycete Fungi.Characterization of a yeast sporulation-specific P450 family protein, Dit2, using an in vitro assay to crosslink formyl tyrosine.Molecular Basis for the Transport of Cytochrome P450 2E1 to the Plasma Membrane
P2860
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P2860
Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
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1984年学术文章
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1984年学术文章
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1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
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1984年學術文章
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name
Signal recognition particle is ...... -450 into microsomal membranes
@ast
Signal recognition particle is ...... -450 into microsomal membranes
@en
type
label
Signal recognition particle is ...... -450 into microsomal membranes
@ast
Signal recognition particle is ...... -450 into microsomal membranes
@en
prefLabel
Signal recognition particle is ...... -450 into microsomal membranes
@ast
Signal recognition particle is ...... -450 into microsomal membranes
@en
P2093
P2860
P356
P1476
Signal recognition particle is ...... -450 into microsomal membranes
@en
P2093
P2860
P304
P356
10.1073/PNAS.81.11.3361
P407
P577
1984-06-01T00:00:00Z