Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
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SETD2: an epigenetic modifier with tumor suppressor functionalityAcetylation Reader Proteins: Linking Acetylation Signaling to Genome Maintenance and CancerGenomic aberrations frequently alter chromatin regulatory genes in chordoma.Improving the reliability of peer-reviewed publications: We are all in it together.Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR InhibitorsMolecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets.BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.Distinct molecular profile of diffuse cerebellar gliomas.SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis.AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells.Marked for death: targeting epigenetic changes in cancer.Influence of Arsenic on Global Levels of Histone Posttranslational Modifications: a Review of the Literature and Challenges in the FieldLymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms.The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children.SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Control of Mus81 nuclease during the cell cycle.MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.It Takes a Village to Unmask HSTL.Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.Mutational status of TP53 defines the efficacy of Wee1 inhibitor AZD1775 in KRAS-mutant non-small cell lung cancer.Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage.Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis.Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience.SETD2: a complex role in blood malignancy.Development of Chemotherapy with Cell-Cycle Inhibitors for Adult and Pediatric Cancer Therapy.PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.Directing the use of DDR kinase inhibitors in cancer treatment.Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis.Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder.Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine.Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers.
P2860
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P2860
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
@ast
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
@en
type
label
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
@ast
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
@en
prefLabel
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
@ast
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
@en
P2093
P2860
P50
P1433
P1476
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
@en
P2093
Chen-Chun Pai
Giulia Orlando
Grigory L Dianov
Ioanna Mavrommati
Mick Woodcock
Nicholas B La Thangue
Songmin Ying
Sophia X Pfister
Sovan Sarkar
Timothy C Humphrey
P2860
P304
P356
10.1016/J.CCELL.2015.09.015
P577
2015-10-20T00:00:00Z