Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. - Wikidata - wikimedia - TriplyDB

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

http://www.wikidata.org/entity/Q36288907

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A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 Protein kinases and phosphatases in the control of cell fate PP2A-twins is antagonized by greatwall and collaborates with polo for cell cycle progression and centrosome attachment to nuclei in drosophila embryos Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression Influence of proline-rich inositol polyphosphate 5-phosphatase, on early development of fertilized mouse eggs, via inhibition of phosphorylation of Akt.A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C.Entrainment of the mammalian cell cycle by the circadian clock: modeling two coupled cellular rhythms.Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair.Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair S100A8/A9 (calprotectin) negatively regulates G2/M cell cycle progression and growth of squamous cell carcinoma.Phosphatases: the new brakes for cancer development?HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function De novo missense variants in PPP2R5D are associated with intellectual disability, macrocephaly, hypotonia, and autism BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression.Cdc25B phosphatase participates in maintaining metaphase II arrest in mouse oocytes.Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.PP2A as a master regulator of the cell cycle.miR-142-3p inhibits cancer cell proliferation by targeting CDC25C.Protein kinase D isozymes activation and localization during mitosis.TRPV3 Channel Negatively Regulates Cell Cycle Progression and Safeguards the Pluripotency of Embryonic Stem Cells.Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression.Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis.A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cells.FGF inhibits the activity of the cyclin B1/CDK1 kinase to induce a transient G₂arrest in RCS chondrocytes.Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.Global gene expression analysis combined with a genomics approach for the identification of signal transduction networks involved in postnatal mouse myocardial proliferation and development.Therapeutic Targeting of PP2A.Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.

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P2860

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

http://www.wikidata.org/entity/Q36288907

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

@ast

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

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type

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Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

@ast

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

@en

prefLabel

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

@ast

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1

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Craig M Forester

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Jessica Maddox

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Jozef Goris

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Justin V Louis

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P2860

Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.

The tumor suppressor PP2A Abeta regulates the RalA GTPase

Shugoshin collaborates with protein phosphatase 2A to protect cohesin

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.

The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15

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50

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104

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5791015

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18056802

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2148389

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