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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

http://www.wikidata.org/entity/Q36290277

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A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor Pleiotropic role of HSF1 in neoplastic transformation IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis.The NF1 gene revisited - from bench to bedside.3'LIFE: a functional assay to detect miRNA targets in high-throughput The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma.FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification.Mutant p53 - Heat Shock Response Oncogenic Cooperation: A New Mechanism of Cancer Cell Survival.Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.HSF1: Guardian of Proteostasis in Cancer The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages Hsp90, an unlikely ally in the war on cancer.miR-107 regulates tumor progression by targeting NF1 in gastric cancer.Clinical and Molecular Characteristics of NF1-Mutant Lung Cancer.HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth.ErbB2 inhibition by lapatinib promotes degradation of mutant p53 protein in cancer cells.A gain-of-function mutant p53-HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress.Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.When Cancer Fights Back: Multiple Myeloma, Proteasome Inhibition, and the Heat-Shock Response.Multifaceted roles of HSF1 in cancer.Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases.Metabolic control of the proteotoxic stress response: implications in diabetes mellitus and neurodegenerative disorders.Metabolic stressors disrupt proteome homeostasis to suppress malignancy Targeting HSF1 sensitizes cancer cells to HSP90 inhibition.Loss of AMPK activation promotes the invasion and metastasis of pancreatic cancer through an HSF1-dependent pathway Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma.Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth.Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.Rethinking HSF1 in Stress, Development, and Organismal Health.Regulation of heat shock transcription factors and their roles in physiology and disease.

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P2860

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

http://www.wikidata.org/entity/Q36290277

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

@en

type

label

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

@ast

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

@en

prefLabel

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

@ast

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

@en

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Journal of Clinical Investigation

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Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

@en

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Chengkai Dai

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Hyoungtae Kwon

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Jiayuan Shi

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Junxia Cao

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Roderick T Bronson

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Sandro Santagata

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Zijian Tang

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P2860

Somatic mutations in the neurofibromatosis 1 gene in human tumors

Proinvasion metastasis drivers in early-stage melanoma are oncogenes.

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress

BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation.

S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein.

Adapting proteostasis for disease intervention

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10

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122

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Susan Lindquist

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2012-09-04T00:00:00Z

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22945628

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3461912

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