The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells
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Do the A subunits contribute to the differences in the toxicity of Shiga toxin 1 and Shiga toxin 2?The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1.Functional divergence between the two P1-P2 stalk dimers on the ribosome in their interaction with ricin A chainHuman ribosomal P1-P2 heterodimer represents an optimal docking site for ricin A chain with a prominent role for P1 C-terminus.Disruption of the ribosomal P complex leads to stress-induced autophagy.Targeting ricin to the ribosome.Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalkCrystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2.Structural insights into the interaction of the ribosomal P stalk protein P2 with a type II ribosome-inactivating protein ricin.Ricin uses arginine 235 as an anchor residue to bind to P-proteins of the ribosomal stalk.Structures of eukaryotic ribosomal stalk proteins and its complex with trichosanthin, and their implications in recruiting ribosome-inactivating proteins to the ribosomes.Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.Functional Assays for Measuring the Catalytic Activity of Ribosome Inactivating Proteins.Peptide Mimics of the Ribosomal P Stalk Inhibit the Activity of Ricin A Chain by Preventing Ribosome Binding
P2860
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P2860
The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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name
The P1/P2 proteins of the huma ...... nation by ricin in human cells
@ast
The P1/P2 proteins of the huma ...... nation by ricin in human cells
@en
type
label
The P1/P2 proteins of the huma ...... nation by ricin in human cells
@ast
The P1/P2 proteins of the huma ...... nation by ricin in human cells
@en
prefLabel
The P1/P2 proteins of the huma ...... nation by ricin in human cells
@ast
The P1/P2 proteins of the huma ...... nation by ricin in human cells
@en
P2093
P2860
P50
P1433
P1476
The P1/P2 proteins of the huma ...... nation by ricin in human cells
@en
P2093
Juan P G Ballesta
Kerrie L May
Nilgun E Tumer
Xiao-Ping Li
P2860
P304
P356
10.1111/J.1742-4658.2012.08752.X
P407
P577
2012-09-11T00:00:00Z