Principles and applications of LC-MS in new drug discovery.
about
Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studiesPharmacokinetic Studies of Chinese Medicinal Herbs Using an Automated Blood Sampling System and Liquid Chromatography-mass SpectrometryThe Applications and Features of Liquid Chromatography-Mass Spectrometry in the Analysis of Traditional Chinese MedicineData-independent microbial metabolomics with ambient ionization mass spectrometry.Pre-processing liquid chromatography/high-resolution mass spectrometry data: extracting pure mass spectra by deconvolution from the invariance of isotopic distribution.A batch correction method for liquid chromatography-mass spectrometry data that does not depend on quality control samplesAccurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plantsRecent application of analytical methods to phase I and phase II drugs development: a review.Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.Internal standard strategies for relative and absolute quantitation of peptides in biological matrices by liquid chromatography tandem mass spectrometry.Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study.Development of a functional assay to detect inhibitors of Plasmodium falciparum glutathione reductase utilizing liquid chromatography-mass spectrometry.Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of tigecycline in rat brain tissues.ADME of biologics-what have we learned from small molecules?Development and validation of HPLC-MS/MS method for the determination of lixivaptan in mouse plasma and its application in a pharmacokinetic study.Biomarker method validation in anticancer drug developmentApplications of LC-MS in PET radioligand development and metabolic elucidationComparison between Source-induced Dissociation and Collision-induced Dissociation of Ampicillin, Chloramphenicol, Ciprofloxacin, and Oxytetracycline via Mass Spectrometry.NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST.Peptide and protein drug analysis by MS: challenges and opportunities for the discovery environment.High-field asymmetric waveform ion mobility spectrometry with solvent vapor addition: a potential greener bioanalytical technique.Advances in LC platforms for drug discovery.Metabolite structure analysis by high-resolution MS: supporting drug-development studies.Predicting the Enzymatic Hydrolysis Half-lives of New Chemicals Using Support Vector Regression Models Based on Stepwise Feature Elimination.Discovery bioanalysis and in vivo pharmacology as an integrated process: a case study in oncology drug discovery.Recent (2000-2015) developments in the analysis of minor unknown natural products based on characteristic fragment information using LC-MS.Capillary microsampling of whole blood for mouse PK studies: an easy route to serial blood sampling.Evaluation of two blood microsampling approaches for drug discovery PK studies in rats.Applications of high-resolution MS in bioanalysis.The future key role of LC-high-resolution-MS analyses in clinical laboratories: a focus on quantification.HRMS using a Q-Exactive series mass spectrometer for regulated quantitative bioanalysis: how, when, and why to implement.Automated non-stepwise preparation of bioanalytical calibration standards and quality controls using an ultra-low volume digitizing liquid dispenser.Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry.Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results from Hemolyzed Samples.Ultra-performance hydrophilic interaction LC-MS/MS for the determination of metformin in mouse plasma.Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats.Structural analysis of 2-arylidene-1-indanone derivatives by electrospray ionization tandem mass spectrometry.Multi-stage mass spectrometric information obtained by deconvolution of energy-resolved spectra acquired by triple-quadrupole mass spectrometry.Use of high-resolution mass spectrometry to investigate a metabolite interference during liquid chromatography/tandem mass spectrometric quantification of a small molecule in toxicokinetic study samples.A rapid HPLC-MS/MS method for the simultaneous quantification of cyclosporine A, tacrolimus, sirolimus and everolimus in human blood samples.
P2860
Q23919157-F827694E-8141-46B1-B54D-FCD1BAABAAAEQ27006864-E815007C-052A-402D-8C55-5F22C958B207Q28067046-532AB62A-D23E-42FA-8B33-A65E7BC7598AQ30541588-7C9BD0F8-7B6B-46AE-870F-F777E741CD12Q30617476-46AC3278-F278-4E97-8D40-C33FAE3A3FFAQ31074641-68CB8C70-2E97-47FD-8838-5F389F1F2F67Q33457706-38740BB8-2741-4C6D-9D1B-46421FA48657Q33997398-D33AF670-CE89-4C41-B06E-0EBE7DE25909Q34070380-65BF8AE1-B1B6-4233-B9F7-A32D37327991Q34310103-EB17DA00-F975-48A1-8B0D-DD8345195DB2Q34672731-81CC7D14-B83D-4E4D-8B7D-D03CEC336DE6Q35740961-135DF034-C983-4A63-BF1B-2E19533ED6CEQ35778366-8B4842E1-3B2E-4E17-A47E-D3F267B2EB10Q36065589-71308547-6810-4EA4-9B02-6A40F77C2215Q36368786-20C362DE-39A0-404B-9819-B977F421719CQ36484621-8C0B9A5A-A890-45F3-B35B-F4F01423E07AQ36777416-2CFB3CA2-7BC2-487A-BB42-A4B05ADCCB35Q37326503-B4DCC29D-A592-436D-A64D-A00533C91606Q37810228-FF340969-727B-4ADE-8F9F-EB5F657C5FE6Q37854632-B1B08871-2E77-4D9F-BCBE-C7D2BB4C73F3Q38020526-10C4BC7D-3EF6-4337-B25C-C3E0900460D4Q38028548-979250F2-0B55-4EE4-9360-BDEDFEAFE4A9Q38081958-5D2C4F00-96A6-4081-93BF-562F11DA955DQ38719496-76FCE881-0A70-4B45-AD2A-D7DBD240175EQ38763889-2A6820B4-721E-4256-8EE4-57DCC63806E5Q38875972-11CDE4C5-D78A-4CC4-90D9-8638C4D54B0AQ39130725-1EDF070D-E770-4982-984D-A20E222A7B31Q39134249-E112B922-09D8-4B53-878B-7D9DD49C21BBQ39410386-0ADADA34-BE1D-4BBE-9A38-E98C57BC4D78Q39502600-508C3B01-D2FB-43D0-A837-85AEA641A837Q39557308-05487900-51D1-4F24-A3F6-5B2E91EC078AQ40186489-06148178-77FC-41B0-9EEF-83D8E4B6B9DBQ41927799-4D7F7289-7D1C-4EDF-8533-DEA76E895B12Q42590076-6893ECAD-4E32-4328-AE5F-E450601D80D2Q42807323-76F93539-BDFF-4165-80DD-ECA48858BC88Q43195724-1C876B9C-71E3-4B32-B2FE-D8FC4F21BFD5Q44176634-0F6F479E-C7CF-43A3-8010-B8139BC000ACQ45076301-D76A58D7-9EB6-480A-89E7-A21B58887D7FQ45298385-0D7C1D8B-B976-4012-A8B4-848A15882F9AQ46072595-0B82BDCE-CF8B-47BC-812D-BFDC03F05032
P2860
Principles and applications of LC-MS in new drug discovery.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Principles and applications of LC-MS in new drug discovery.
@ast
Principles and applications of LC-MS in new drug discovery.
@en
type
label
Principles and applications of LC-MS in new drug discovery.
@ast
Principles and applications of LC-MS in new drug discovery.
@en
prefLabel
Principles and applications of LC-MS in new drug discovery.
@ast
Principles and applications of LC-MS in new drug discovery.
@en
P1433
P1476
Principles and applications of LC-MS in new drug discovery.
@en
P2093
Walter A Korfmacher
P304
P356
10.1016/S1359-6446(05)03620-2
P577
2005-10-01T00:00:00Z