Genetic and biochemical characterization of the galactose gene cluster in Kluyveromyces lactis.
about
The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex.Glucose represses the lactose-galactose regulon in Kluyveromyces lactis through a SNF1 and MIG1- dependent pathway that modulates galactokinase (GAL1) gene expressionThe organization and transcription of the galactose gene cluster of Kluyveromyces lactisSynergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response.Genetic evidence for sites of interaction between the Gal3 and Gal80 proteins of the Saccharomyces cerevisiae GAL gene switch.Constitutive expression in gal7 mutants of Kluyveromyces lactis is due to internal production of galactose as an inducer of the Gal/Lac regulon.The C6 zinc finger and adjacent amino acids determine DNA-binding specificity and affinity in the yeast activator proteins LAC9 and PPR1.Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiaeInteraction between transcriptional activator protein LAC9 and negative regulatory protein GAL80GAL4 of Saccharomyces cerevisiae activates the lactose-galactose regulon of Kluyveromyces lactis and creates a new phenotype: glucose repression of the regulonCharacterization of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose regulon of Kluyveromyces lactis: structural and functional relationships to GAL4 of Saccharomyces cerevisiaeCysteine residues in the zinc finger and amino acids adjacent to the finger are necessary for DNA binding by the LAC9 regulatory protein of Kluyveromyces lactisIdentification of upstream activator sequences that regulate induction of the beta-galactosidase gene in Kluyveromyces lactis.A mutation in the Zn-finger of the GAL4 homolog LAC9 results in glucose repression of its target genes.Analysis of the Kluyveromyces lactis positive regulatory gene LAC9 reveals functional homology to, but sequence divergence from, the Saccharomyces cerevisiae GAL4 genePositive regulation of the beta-galactosidase gene from Kluyveromyces lactis is mediated by an upstream activation site that shows homology to the GAL upstream activation site of Saccharomyces cerevisiae.
P2860
Q27935633-B712D8AB-05AF-4847-B898-E3156DF84E47Q34636444-8AEF155C-7796-4D75-A947-C3287F880579Q36063856-AA36D808-E1A4-4418-9689-EB1B99A5C782Q36438390-394110EE-758F-4EE6-B6C5-F26BA2149E71Q36470555-DAD82A76-D3A5-44E1-9311-457ABA4249CBQ36566218-708A7B54-72F3-4433-BAA7-251CC35526E6Q36727439-2EBA27FD-5AB8-451D-BBDF-37B9B0C3BB8FQ36747009-76E8548A-FCAF-4A0B-9CC3-F51F5AF41C1CQ36769596-E0E3717F-AE6B-499C-AB83-281BC9A97DC2Q36835247-8BC0F494-C881-4CAB-A293-C4ECA59AA82EQ36837016-29EC7BAD-7120-4949-A96C-99683217B7A8Q36844831-D44013A6-0E3A-4642-8D79-6314BC372F45Q36925274-7A893330-34B0-4ED2-A1C5-E8B925804CA5Q38341901-669C86DD-DA0F-4040-ABD1-18243C099E79Q40418940-35AECCDC-15DD-4A97-8DA6-A28ACCB173B6Q40658682-6FC7C805-55FA-4DCC-B970-FC2C88800773
P2860
Genetic and biochemical characterization of the galactose gene cluster in Kluyveromyces lactis.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh
1984年學術文章
@zh-hant
name
Genetic and biochemical charac ...... uster in Kluyveromyces lactis.
@ast
Genetic and biochemical charac ...... uster in Kluyveromyces lactis.
@en
type
label
Genetic and biochemical charac ...... uster in Kluyveromyces lactis.
@ast
Genetic and biochemical charac ...... uster in Kluyveromyces lactis.
@en
prefLabel
Genetic and biochemical charac ...... uster in Kluyveromyces lactis.
@ast
Genetic and biochemical charac ...... uster in Kluyveromyces lactis.
@en
P2860
P1476
Genetic and biochemical charac ...... luster in Kluyveromyces lactis
@en
P2093
R C Dickson
P2860
P304
P407
P577
1984-05-01T00:00:00Z