Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain - Wikidata - wikimedia - TriplyDB

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

http://www.wikidata.org/entity/Q36300887

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Progress and perspectives on targeting nanoparticles for brain drug delivery.Immune interventions in stroke Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.The outbreak fingolimod cardiovascular side effects in relapsing-remitting multiple sclerosis patient: A longitudinal study in an Iranian population.Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmaco Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient.Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?In vitro cerebrovascular modeling in the 21st century: current and prospective technologies.Cardiovascular effects of fingolimod: A review article.Impact of an immune modulator fingolimod on acute ischemic stroke.Unmasking and provoking severe disease activity in a patient with NMO spectrum disorder ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis.Regulation of ABC transporters at the blood-brain barrier.Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic Stroke: A Pilot Trial.Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.Apicobasal polarity of brain endothelial cells.Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers.Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells.Blood-brain barrier remodeling during brain metastasis formation.Inflammatory Disequilibrium in Stroke Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule.Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research.The blood-brain barrier: an engineering perspective.Pharmacokinetic evaluation of fingolimod for the treatment of multiple sclerosis.Molecular pharmacodynamics of new oral drugs used in the treatment of multiple sclerosis P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery.Drug delivery to the ischemic brain.P-glycoprotein and membrane roles in multidrug resistance.Effects of hepatic ischemia-reperfusion injury on the blood-brain barrier permeability to [(14)C] and [(13)C]sucrose.Sepsis-Associated Encephalopathy: The Blood-Brain Barrier and the Sphingolipid Rheostat.Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells.FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1.Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain.Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts.Cell-free microfluidic determination of P-glycoprotein interactions with substrates and inhibitors.PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.

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P2860

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

http://www.wikidata.org/entity/Q36300887

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2012 nî lūn-bûn

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Targeting blood-brain barrier ...... ves drug delivery to the brain

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Targeting blood-brain barrier ...... ves drug delivery to the brain

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Targeting blood-brain barrier ...... ves drug delivery to the brain

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Proceedings of the National Academy of Sciences of the United States of America

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Targeting blood-brain barrier ...... ves drug delivery to the brain

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Christopher R Campos

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John C Peart

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Ronald E Cannon

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P2860

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

Oral treatment for multiple sclerosis

Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor

Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier

Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier

Structure and function of the blood-brain barrier

P-glycoprotein acts as an immunomodulator during neuroinflammation.

Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.

Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.

Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier

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15930-15935

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scholarly article

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10.1073/PNAS.1203534109

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39

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109

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David S. Miller

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230798527

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22949658

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blood–brain barrier

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3465435

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