Op18/stathmin mediates multiple region-specific tubulin and microtubule-regulating activities.
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Op18/stathmin caps a kinked protofilament-like tubulin tetramerIdentification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assemblyThe Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in DrosophilaThermodynamics of the Op18/stathmin-tubulin interactionStathmin regulates centrosomal nucleation of microtubules and tubulin dimer/polymer partitioning.Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry.Drosophila stathmins bind tubulin heterodimers with high and variable stoichiometries.Recognition between flexible protein molecules: induced and assisted folding.Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electrophoresis.The catastrophe-promoting activity of ectopic Op18/stathmin is required for disruption of mitotic spindles but not interphase microtubulesStathmin/Op18 phosphorylation is regulated by microtubule assembly.Stat3 regulates microtubules by antagonizing the depolymerization activity of stathminIdentification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth.Proteins pattern alteration in AZT-treated K562 cells detected by two-dimensional gel electrophoresis and peptide mass fingerprinting.Deciphering the cellular functions of the Op18/Stathmin family of microtubule-regulators by plasma membrane-targeted localization.Structural transitions at microtubule ends correlate with their dynamic properties in Xenopus egg extracts.A synergistic relationship between three regions of stathmin family proteins is required for the formation of a stable complex with tubulin.Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells.Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin.The effect of stathmin phosphorylation on microtubule assembly depends on tubulin critical concentration.Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation.Molecular dissection of GTP exchange and hydrolysis within the ternary complex of tubulin heterodimers and Op18/stathmin family members.Stathmin strongly increases the minus end catastrophe frequency and induces rapid treadmilling of bovine brain microtubules at steady state in vitro.Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain.The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases.
P2860
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P2860
Op18/stathmin mediates multiple region-specific tubulin and microtubule-regulating activities.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Op18/stathmin mediates multipl ...... otubule-regulating activities.
@ast
Op18/stathmin mediates multipl ...... otubule-regulating activities.
@en
type
label
Op18/stathmin mediates multipl ...... otubule-regulating activities.
@ast
Op18/stathmin mediates multipl ...... otubule-regulating activities.
@en
prefLabel
Op18/stathmin mediates multipl ...... otubule-regulating activities.
@ast
Op18/stathmin mediates multipl ...... otubule-regulating activities.
@en
P2093
P2860
P356
P1476
Op18/stathmin mediates multipl ...... otubule-regulating activities.
@en
P2093
P2860
P304
P356
10.1083/JCB.146.6.1289
P407
P577
1999-09-01T00:00:00Z