Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics.
about
Calmodulin regulation (calmodulation) of voltage-gated calcium channelsTowards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium ChannelsPerspective: a dynamics-based classification of ventricular arrhythmiasSuppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazineIntra- and interdomain effects due to mutation of calcium-binding sites in calmodulinVoltage and calcium dynamics both underlie cellular alternans in cardiac myocytes.Mechanisms and determinants of ultralong action potential duration and slow rate-dependence in cardiac myocytes.The role of Purkinje-myocardial coupling during ventricular arrhythmia: a modeling studyBiomaterial based cardiac tissue engineering and its applicationsRole of substrate and triggers in the genesis of cardiac alternans, from the myocyte to the whole heart: implications for therapy.Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs.Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers.Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca(2+)-dependent inactivationMechanisms Underlying AF: Triggers, Rotors, Other?The link between abnormal calcium handling and electrical instability in acquired long QT syndrome--Does calcium precipitate arrhythmic storms?Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handlingT-wave alternans as an arrhythmic risk stratifier: state of the artAccelerated inactivation of cardiac L-type calcium channels triggered by anaesthetic-induced preconditioning.Sensitivity of rabbit ventricular action potential and Ca²⁺ dynamics to small variations in membrane currents and ion diffusion coefficients.Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress.Rad GTPase deletion increases L-type calcium channel current leading to increased cardiac contraction.A translational approach to probe the proarrhythmic potential of cardiac alternans: a reversible overture to arrhythmogenesis?Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation.Spontaneous high-frequency action potential.Redox control of cardiac excitability.Bifurcation theory and cardiac arrhythmias.A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory.Studying dyadic structure-function relationships: a review of current modeling approaches and new insights into Ca2+ (mis)handling.Rabbit-specific computational modelling of ventricular cell electrophysiology: Using populations of models to explore variability in the response to ischemia.Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels.The role of fine-scale anatomical structure in the dynamics of reentry in computational models of the rabbit ventricles.Conservation of Ca2+/calmodulin regulation across Na and Ca2+ channels.Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia.Mesenchymal stem cells suppress cardiac alternans by activation of PI3K mediated nitroso-redox pathway.Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity.Mechanisms of ventricular rate adaptation as a predictor of arrhythmic risk.Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes.Calcium-Dependent Arrhythmogenic Foci Created by Weakly Coupled Myocytes in the Failing Heart.Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations.
P2860
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P2860
Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Modifying L-type calcium curre ...... ation and arrhythmia dynamics.
@ast
Modifying L-type calcium curre ...... ation and arrhythmia dynamics.
@en
type
label
Modifying L-type calcium curre ...... ation and arrhythmia dynamics.
@ast
Modifying L-type calcium curre ...... ation and arrhythmia dynamics.
@en
prefLabel
Modifying L-type calcium curre ...... ation and arrhythmia dynamics.
@ast
Modifying L-type calcium curre ...... ation and arrhythmia dynamics.
@en
P2093
P2860
P1433
P1476
Modifying L-type calcium curre ...... ation and arrhythmia dynamics.
@en
P2093
Alan Garfinkel
Aman Mahajan
Daisuke Sato
James N Weiss
Lai-Hua Xie
Riccardo Olcese
Robert Peralta
Yohannes Shiferaw
P2860
P304
P356
10.1529/BIOPHYSJ.106.98590
P407
P577
2008-01-01T00:00:00Z