Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells - Wikidata - wikimedia - TriplyDB

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells

http://www.wikidata.org/entity/Q36304128

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Cancer stem cell metabolism Targeting hypoxic response for cancer therapy Pathophysiological mechanisms of death resistance in colorectal carcinoma Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery The ever-expanding role of HIF in tumour and stromal biology Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1α/OATPs signaling axis Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma Silencing of reversion-inducing cysteine-rich protein with Kazal motifs stimulates hyperplastic phenotypes through activation of epidermal growth factor receptor and hypoxia-inducible factor-2α.Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets.Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo.Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition.Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells.Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma.Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.Targeting metabolic plasticity in breast cancer cells via mitochondrial complex I modulation.How cancer cells dictate their microenvironment: present roles of extracellular vesicles.Targeting mitochondrial function for the treatment of breast cancer.Roles of hypoxia, stem cells and epithelial-mesenchymal transition in the spread and treatment resistance of head and neck cancer.HIF2α is involved in the expansion of CXCR4-positive cancer stem-like cells in renal cell carcinoma.Cezanne regulates E2F1-dependent HIF2α expression.Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy.Cancer metabolism: new validated targets for drug discovery.Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development.Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment.TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer.Angiogenesis in spontaneous tumors and implications for comparative tumor biology.HIF-1α and mTOR - Possible Novel Strategies of Targeted Therapies in p16-positive and -negative HNSCC.Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.Cancer stem cells (CSCs): metabolic strategies for their identification and eradication.Hypoxic Signalling in Tumour Stroma.Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts.Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT

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Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells

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Metabolic reprogramming and tw ...... and human breast cancer cells

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Metabolic reprogramming and tw ...... and human breast cancer cells

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Metabolic reprogramming and tw ...... and human breast cancer cells

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Anthony Howell

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Barbara Chiavarina

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Richard G Pestell

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Ubaldo E Martinez-Outschoorn

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P2860

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

Stromal cell expression of caveolin-1 predicts outcome in breast cancer

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

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3280-3289

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10.4161/CC.21643

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17

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11

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Michael P. Lisanti

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Herbert B Tanowitz

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3466527

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