alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.
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Skin Carcinogenesis Studies Using Mouse Models with Altered Polyamines.Polyamines and cancer: implications for chemotherapy and chemopreventionPronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase genePolyamines and nonmelanoma skin cancer.Perspectives in cancer chemoprevention.Mechanisms of asbestos-induced squamous metaplasia in tracheobronchial epithelial cells.A perspective of polyamine metabolism.Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.The chemotherapeutic potential of polyamine antimetabolites.Ornithine decarboxylase from mouse epidermis and epidermal papillomas: differences in enzymatic properties and structure.Polyamines: from molecular biology to clinical applications.Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding.Focal smooth muscle proliferation in the aortic intima produced by an initiation-promotion sequence.Polyamines metabolism and breast cancer: state of the art and perspectives.Ornithine decarboxylase: a key regulatory enzyme in normal and neoplastic growth.Initiation-promotion versus complete skin carcinogenesis in mice: importance of dark basal keratinocytes (stem cells).Induction of epithelial differentiation and DNA demethylation in hamster malignant oral keratinocyte by ornithine decarboxylase antizyme.Validity of short-term examination for antipromoters of bladder carcinogenesis.Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.Core promoter involvement in the induction of rat ornithine decarboxylase by phorbol esters.Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression.Molecular mechanisms of mouse skin tumor promotion.Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice.Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention.Herbacetin suppresses cutaneous squamous cell carcinoma and melanoma cell growth by targeting AKT and ODC.Induction of ornithine decarboxylase and augmentation of tyrosine aminotransferase activity by N-hydroxy-2-acetylaminofluorene and 2-acetylaminofluorene in rat liver. Influence of sex, retinylacetate, indomethacin, and pentachlorophenol.Tumor promoter-induced ornithine decarboxylase gene expression occurs independently of AP-1 activation.
P2860
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P2860
alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.
description
1982 nî lūn-bûn
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1982年の論文
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1982年学术文章
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1982年学术文章
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1982年学术文章
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1982年学术文章
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1982年學術文章
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name
alpha-Difluoromethylornithine, ...... carcinogenesis in mouse skin.
@ast
alpha-Difluoromethylornithine, ...... carcinogenesis in mouse skin.
@en
type
label
alpha-Difluoromethylornithine, ...... carcinogenesis in mouse skin.
@ast
alpha-Difluoromethylornithine, ...... carcinogenesis in mouse skin.
@en
prefLabel
alpha-Difluoromethylornithine, ...... carcinogenesis in mouse skin.
@ast
alpha-Difluoromethylornithine, ...... carcinogenesis in mouse skin.
@en
P2093
P2860
P356
P1476
alpha-Difluoromethylornithine, ...... carcinogenesis in mouse skin.
@en
P2093
P2860
P304
P356
10.1073/PNAS.79.19.6028
P407
P577
1982-10-01T00:00:00Z