The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex.
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The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusionRILP interacts with HOPS complex via VPS41 subunit to regulate endocytic traffickingThe DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8.The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegansProtein kinases associated with the yeast phosphoproteome.Coat/Tether Interactions-Exception or Rule?Organelle acidification negatively regulates vacuole membrane fusion in vivo.The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles.Distinct palmitoylation events at the amino-terminal conserved cysteines of Env7 direct its stability, localization, and vacuolar fusion regulation in S. cerevisiaeAn overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking.Genome-wide analysis of AP-3-dependent protein transport in yeastThe Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuolesp21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.The HOPS/Class C Vps Complex Tethers High-Curvature Membranes via a Direct Protein-Membrane Interaction.The HOPS/class C Vps complex tethers membranes by binding to one Rab GTPase in each apposed membrane.The yeast vacuolar Rab GTPase Ypt7p has an activity beyond membrane recruitment of the homotypic fusion and protein sorting-Class C Vps complexPhosphorylation of the effector complex HOPS by the vacuolar kinase Yck3p confers Rab nucleotide specificity for vacuole docking and fusion.The vacuole system is a significant intracellular pathway for longitudinal solute transport in basidiomycete fungiHOPS interacts with Apl5 at the vacuole membrane and is required for consumption of AP-3 transport vesicles.Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements.Ypt1/Rab1 regulates Hrr25/CK1δ kinase activity in ER-Golgi traffic and macroautophagy.Vps-C complexes: gatekeepers of endolysosomal traffic.Osmotic regulation of Rab-mediated organelle dockingDynamic association of the PI3P-interacting Mon1-Ccz1 GEF with vacuoles is controlled through its phosphorylation by the type 1 casein kinase Yck3.HOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly.Tracking of the dynamic localization of the Rab-specific HOPS subunits reveal their distinct interaction with Ypt7 and vacuoles.Phosphorylation of a membrane curvature-sensing motif switches function of the HOPS subunit Vps41 in membrane tethering.Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation.Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiaeThe N-terminal domains of Vps3 and Vps8 are critical for localization and function of the CORVET tethering complex on endosomes.Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion.The Vps39-like TRAP1 is an effector of Rab5 and likely the missing Vps3 subunit of human CORVETMetazoan cell biology of the HOPS tethering complexThe yeast Batten disease orthologue Btn1 controls endosome-Golgi retrograde transport via SNARE assembly.Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1.Excess vacuolar SNAREs drive lysis and Rab bypass fusion
P2860
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P2860
The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex.
description
2005 nî lūn-bûn
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2005年の論文
@ja
2005年学术文章
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2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
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2005年學術文章
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2005年學術文章
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name
The vacuolar kinase Yck3 maint ...... ng the HOPS tethering complex.
@ast
The vacuolar kinase Yck3 maint ...... ng the HOPS tethering complex.
@en
type
label
The vacuolar kinase Yck3 maint ...... ng the HOPS tethering complex.
@ast
The vacuolar kinase Yck3 maint ...... ng the HOPS tethering complex.
@en
prefLabel
The vacuolar kinase Yck3 maint ...... ng the HOPS tethering complex.
@ast
The vacuolar kinase Yck3 maint ...... ng the HOPS tethering complex.
@en
P2860
P356
P1476
The vacuolar kinase Yck3 maint ...... ng the HOPS tethering complex.
@en
P2093
Christian Ungermann
Tracy J LaGrassa
P2860
P304
P356
10.1083/JCB.200407141
P407
P577
2005-01-01T00:00:00Z