Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins.
about
Hepatitis B precore protein: pathogenic potential and therapeutic promiseStability engineering of the human antibody repertoireAtypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural AnalysisThe structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulinsFish ImmunoglobulinsDiscovery of a unique Ig heavy-chain isotype (IgT) in rainbow trout: Implications for a distinctive B cell developmental pathway in teleost fish.Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigenA preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana)A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis.ES1, a new lung carcinoma antibody--an immunohistochemical study.Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library.Protocol for the selection of single-domain antibody fragments by third generation intracellular antibody capture.On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domesticaA case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early development and is convergent with mammalian IgG.Construction of an artificially randomized IgNAR phage display library: screening of variable regions that bind to hen egg white lysozyme.First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate.Human TNF cytokine neutralization with a vNAR from Heterodontus francisci shark: a potential therapeutic useAn evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks.The immunoglobulins of cold-blooded vertebratesEngineered antibody variable and constant domains as therapeutic candidates.High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin DomainsA unique T cell receptor discovered in marsupials.In an immunological twilight zone.'In-Format' screening of a novel bispecific antibody format reveals significant potency improvements relative to unformatted molecules.Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy.The plasticity of immunoglobulin gene systems in evolution.Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centersExpression of heavy chain-only antibodies can support B-cell development in light chain knockout chickens.Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor.Structure and function of immunoglobulinsNovel therapy based on camelid nanobodies.Shark variable new antigen receptor biologics - a novel technology platform for therapeutic drug development.Structural insights and biomedical potential of IgNAR scaffolds from sharks.Analysis of the binding loops configuration and surface adaptation of different crystallized single-domain antibodies in response to various antigens.Passive Immunization of Farmed Fish.Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.Dual beneficial effect of interloop disulfide bond for single domain antibody fragments.Single-Domain Antibodies As Versatile Affinity Reagents for Analytical and Diagnostic Applications.Structure of a shark IgNAR antibody variable domain and modeling of an early-developmental isotype.
P2860
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P2860
Structural analysis of the nurse shark (new) antigen receptor (NAR): molecular convergence of NAR and unusual mammalian immunoglobulins.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Structural analysis of the nur ...... ual mammalian immunoglobulins.
@ast
Structural analysis of the nur ...... ual mammalian immunoglobulins.
@en
type
label
Structural analysis of the nur ...... ual mammalian immunoglobulins.
@ast
Structural analysis of the nur ...... ual mammalian immunoglobulins.
@en
prefLabel
Structural analysis of the nur ...... ual mammalian immunoglobulins.
@ast
Structural analysis of the nur ...... ual mammalian immunoglobulins.
@en
P2093
P2860
P356
P1476
Structural analysis of the nur ...... ual mammalian immunoglobulins.
@en
P2093
P2860
P304
11804-11809
P356
10.1073/PNAS.95.20.11804
P407
P577
1998-09-01T00:00:00Z